Missing pieces in the NF-kappaB puzzle - PubMed (original) (raw)

Review

. 2002 Apr:109 Suppl:S81-96.

doi: 10.1016/s0092-8674(02)00703-1.

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• PMID: 11983155
• DOI: 10.1016/s0092-8674(02)00703-1

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Review

Missing pieces in the NF-kappaB puzzle

Sankar Ghosh et al. Cell. 2002 Apr.

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Abstract

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

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