A caspase-related protease regulates apoptosis in yeast - PubMed (original) (raw)
A caspase-related protease regulates apoptosis in yeast
Frank Madeo et al. Mol Cell. 2002 Apr.
Free article
Abstract
Yeast can undergo cell death accompanied by cellular markers of apoptosis. However, orthologs of classical mammalian apoptosis regulators appeared to be missing from the yeast genome, challenging a common mechanism of yeast and mammalian apoptosis. Here we investigate Yor197w, a yeast protein with structural homology to mammalian caspases, and demonstrate caspase-like processing of the protein. Hydrogen peroxide treatment induces apoptosis together with a caspase-like enzymatic activity in yeast. This response is completely abrogated after disruption and strongly stimulated after overexpression of Yor197w. Yor197w also mediates the death process within chronologically aged cultures, pointing to a physiological role in elimination of overaged cells. We conclude that Yor197w indeed functions as a bona fide caspase in yeast and propose the name Yeast Caspase-1 (YCA1, gene YCA1).
Similar articles
- Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death.
Bettiga M, Calzari L, Orlandi I, Alberghina L, Vai M. Bettiga M, et al. FEMS Yeast Res. 2004 Nov;5(2):141-7. doi: 10.1016/j.femsyr.2004.07.005. FEMS Yeast Res. 2004. PMID: 15489197 - A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae.
Szallies A, Kubata BK, Duszenko M. Szallies A, et al. FEBS Lett. 2002 Apr 24;517(1-3):144-50. doi: 10.1016/s0014-5793(02)02608-x. FEBS Lett. 2002. PMID: 12062425 - An AIF orthologue regulates apoptosis in yeast.
Wissing S, Ludovico P, Herker E, Büttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Fröhlich KU, Manns J, Candé C, Sigrist SJ, Kroemer G, Madeo F. Wissing S, et al. J Cell Biol. 2004 Sep 27;166(7):969-74. doi: 10.1083/jcb.200404138. Epub 2004 Sep 20. J Cell Biol. 2004. PMID: 15381687 Free PMC article. - Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways.
Guaragnella N, Antonacci L, Passarella S, Marra E, Giannattasio S. Guaragnella N, et al. Biochem Soc Trans. 2011 Oct;39(5):1538-43. doi: 10.1042/BST0391538. Biochem Soc Trans. 2011. PMID: 21936848 Review. - Caspase-dependent apoptosis in yeast.
Mazzoni C, Falcone C. Mazzoni C, et al. Biochim Biophys Acta. 2008 Jul;1783(7):1320-7. doi: 10.1016/j.bbamcr.2008.02.015. Epub 2008 Feb 29. Biochim Biophys Acta. 2008. PMID: 18355456 Review.
Cited by
- Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest.
Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM. Bode M, et al. Antioxid Redox Signal. 2013 May 1;18(13):1597-612. doi: 10.1089/ars.2012.4685. Epub 2013 Jan 15. Antioxid Redox Signal. 2013. PMID: 23198688 Free PMC article. - Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid.
Giannattasio S, Guaragnella N, Zdralević M, Marra E. Giannattasio S, et al. Front Microbiol. 2013 Feb 20;4:33. doi: 10.3389/fmicb.2013.00033. eCollection 2013. Front Microbiol. 2013. PMID: 23430312 Free PMC article. - Crystal structure of the yeast metacaspase Yca1.
Wong AH, Yan C, Shi Y. Wong AH, et al. J Biol Chem. 2012 Aug 24;287(35):29251-9. doi: 10.1074/jbc.M112.381806. Epub 2012 Jul 2. J Biol Chem. 2012. PMID: 22761449 Free PMC article. - The dual role of a yeast metacaspase: What doesn't kill you makes you stronger.
Hill SM, Nyström T. Hill SM, et al. Bioessays. 2015 May;37(5):525-31. doi: 10.1002/bies.201400208. Epub 2015 Feb 13. Bioessays. 2015. PMID: 25677381 Free PMC article. - The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Akintade DD, Chaudhuri B. Akintade DD, et al. Biosci Rep. 2020 Sep 30;40(9):BSR20201912. doi: 10.1042/BSR20201912. Biosci Rep. 2020. PMID: 32794578 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases