Protons at the gate: DEG/ENaC ion channels help us feel and remember - PubMed (original) (raw)
Review
. 2002 Apr 25;34(3):337-40.
doi: 10.1016/s0896-6273(02)00687-6.
Affiliations
- PMID: 11988165
- DOI: 10.1016/s0896-6273(02)00687-6
Free article
Review
Protons at the gate: DEG/ENaC ion channels help us feel and remember
Laura Bianchi et al. Neuron. 2002.
Free article
Abstract
The DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning.
Similar articles
- A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.
Wang Y, Apicella A Jr, Lee SK, Ezcurra M, Slone RD, Goldmit M, Schafer WR, Shaham S, Driscoll M, Bianchi L. Wang Y, et al. EMBO J. 2008 Sep 17;27(18):2388-99. doi: 10.1038/emboj.2008.161. Epub 2008 Aug 14. EMBO J. 2008. PMID: 18701922 Free PMC article. - The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.
Chelur DS, Ernstrom GG, Goodman MB, Yao CA, Chen L, O' Hagan R, Chalfie M. Chelur DS, et al. Nature. 2002 Dec 12;420(6916):669-73. doi: 10.1038/nature01205. Nature. 2002. PMID: 12478294 - Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons.
Cueva JG, Mulholland A, Goodman MB. Cueva JG, et al. J Neurosci. 2007 Dec 19;27(51):14089-98. doi: 10.1523/JNEUROSCI.4179-07.2007. J Neurosci. 2007. PMID: 18094248 Free PMC article. - H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels.
Waldmann R, Lazdunski M. Waldmann R, et al. Curr Opin Neurobiol. 1998 Jun;8(3):418-24. doi: 10.1016/s0959-4388(98)80070-6. Curr Opin Neurobiol. 1998. PMID: 9687356 Review. - Insight into DEG/ENaC channel gating from genetics and structure.
Eastwood AL, Goodman MB. Eastwood AL, et al. Physiology (Bethesda). 2012 Oct;27(5):282-90. doi: 10.1152/physiol.00006.2012. Physiology (Bethesda). 2012. PMID: 23026751 Free PMC article. Review.
Cited by
- Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization.
Wasson R, Fleming AB, McLin J, Hildebrandt E, Drummond HA. Wasson R, et al. Physiol Rep. 2024 Jul;12(14):e16139. doi: 10.14814/phy2.16139. Physiol Rep. 2024. PMID: 39016176 Free PMC article. - The role of acid sensing ion channels in the cardiovascular function.
López-Ramírez O, González-Garrido A. López-Ramírez O, et al. Front Physiol. 2023 Jun 14;14:1194948. doi: 10.3389/fphys.2023.1194948. eCollection 2023. Front Physiol. 2023. PMID: 37389121 Free PMC article. Review. - βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.
Lu Y, Stec DE, Liu R, Ryan M, Drummond HA. Lu Y, et al. Am J Physiol Renal Physiol. 2022 May 1;322(5):F498-F511. doi: 10.1152/ajprenal.00003.2022. Epub 2022 Mar 14. Am J Physiol Renal Physiol. 2022. PMID: 35285274 Free PMC article. - Ion Selectivity in the ENaC/DEG Family: A Systematic Review with Supporting Analysis.
Vallée C, Howlin B, Lewis R. Vallée C, et al. Int J Mol Sci. 2021 Oct 12;22(20):10998. doi: 10.3390/ijms222010998. Int J Mol Sci. 2021. PMID: 34681656 Free PMC article. - What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells.
Drummond HA. Drummond HA. Physiology (Bethesda). 2021 Sep 1;36(5):292-306. doi: 10.1152/physiol.00008.2021. Physiology (Bethesda). 2021. PMID: 34431420 Free PMC article. Review.