Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells - PubMed (original) (raw)

. 2002 May 3;296(5569):927-31.

doi: 10.1126/science.1067631.

Affiliations

• PMID: 11988579
• DOI: 10.1126/science.1067631

Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells

Anura Rambukkana et al. Science. 2002.

Abstract

Demyelination results in severe disability in many neurodegenerative diseases and nervous system infections, and it is typically mediated by inflammatory responses. Mycobacterium leprae, the causative organism of leprosy, induced rapid demyelination by a contact-dependent mechanism in the absence of immune cells in an in vitro nerve tissue culture model and in Rag1-knockout (Rag1-/-) mice, which lack mature B and T lymphocytes. Myelinated Schwann cells were resistant to M. leprae invasion but undergo demyelination upon bacterial attachment, whereas nonmyelinated Schwann cells harbor intracellular M. leprae in large numbers. During M. leprae-induced demyelination, Schwann cells proliferate significantly both in vitro and in vivo and generate a more nonmyelinated phenotype, thereby securing the intracellular niche for M. leprae.

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Comment in

• Microbiology. Subversion of Schwann cells and the leper's bell.
  Brophy PJ. Brophy PJ. Science. 2002 May 3;296(5569):862-3. doi: 10.1126/science.1072444. Science. 2002. PMID: 11988561 No abstract available.
• Mycobacterium leprae and demyelination.
  Ottenhoff TH. Ottenhoff TH. Science. 2002 Aug 30;297(5586):1475-6; author reply 1475-6. doi: 10.1126/science.297.5586.1475c. Science. 2002. PMID: 12211241 No abstract available.

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