Cell cycle: stressed out of mitosis - PubMed (original) (raw)
Cell cycle: stressed out of mitosis
Alexei Mikhailov et al. Curr Biol. 2002.
Free article
Abstract
Cells in early stages of chromosome condensation are very vulnerable, and many stresses that do not damage DNA induce a transient return to late G2 phase. Such stresses include the drug-induced disassembly of microtubules, which triggers an ATM-independent G2 checkpoint pathway involving a novel ubiquitin ligase.
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