Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning - PubMed (original) (raw)
. 2002 May 16;417(6886):282-7.
doi: 10.1038/417282a.
Affiliations
- PMID: 12015602
- DOI: 10.1038/417282a
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
J Amiel Rosenkranz et al. Nature. 2002.
Abstract
Pavlovian conditioning results when an innocuous stimulus, such as an odour, is paired with a behaviourally relevant stimulus, such as a foot-shock, so that eventually the former stimulus alone will elicit the behavioural response of the latter. The lateral nucleus of the amygdala (LAT) is necessary for the emotional memory formation in this paradigm. Enhanced neuronal firing in LAT to conditioned stimuli emerge in parallel with the behavioural changes and are dependent on local dopamine. To study the changes in neuronal excitability and synaptic drive that contribute to the pavlovian conditioning process, here we used in vivo intracellular recordings to examine LAT neurons during pavlovian conditioning in rats. We found that repeated pairings of an odour with a foot-shock resulted in enhanced post-synaptic potential (PSP) responses to the odour and increased neuronal excitability. However, a non-paired odour displayed PSP decrement. The dopamine antagonist haloperidol blocked the PSP enhancement and associated increased neuronal excitability, without reversing previous conditioning. These results demonstrate that conditioning and habituation processes produce opposite effects on LAT neurons and that dopamine is important in these events, consistent with its role in emotional memory formation.
Similar articles
- The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli.
Rosenkranz JA, Moore H, Grace AA. Rosenkranz JA, et al. J Neurosci. 2003 Dec 3;23(35):11054-64. doi: 10.1523/JNEUROSCI.23-35-11054.2003. J Neurosci. 2003. PMID: 14657162 Free PMC article. - Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.
Schafe GE, Atkins CM, Swank MW, Bauer EP, Sweatt JD, LeDoux JE. Schafe GE, et al. J Neurosci. 2000 Nov 1;20(21):8177-87. doi: 10.1523/JNEUROSCI.20-21-08177.2000. J Neurosci. 2000. PMID: 11050141 Free PMC article. - Fear memories induce a switch in stimulus response and signaling mechanisms for long-term potentiation in the lateral amygdala.
Schroeder BW, Shinnick-Gallagher P. Schroeder BW, et al. Eur J Neurosci. 2004 Jul;20(2):549-56. doi: 10.1111/j.1460-9568.2004.03517.x. Eur J Neurosci. 2004. PMID: 15233764 - Pavlovian conditioning of emotional responses to olfactory and contextual stimuli: a potential model for the development and expression of chemical intolerance.
Otto T, Giardino ND. Otto T, et al. Ann N Y Acad Sci. 2001 Mar;933:291-309. doi: 10.1111/j.1749-6632.2001.tb05832.x. Ann N Y Acad Sci. 2001. PMID: 12000029 Review. - Pavlovian conditioning of the immune system.
Cohen N, Moynihan JA, Ader R. Cohen N, et al. Int Arch Allergy Immunol. 1994 Oct;105(2):101-6. doi: 10.1159/000236811. Int Arch Allergy Immunol. 1994. PMID: 7920010 Review.
Cited by
- No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats.
Schroyens N, Vercammen L, Özcan B, Ossorio Salazar VA, Zaman J, De Bundel D, Beckers T, Luyten L. Schroyens N, et al. J Psychopharmacol. 2024 Jul;38(7):672-682. doi: 10.1177/02698811241261375. Epub 2024 Jul 28. J Psychopharmacol. 2024. PMID: 39068641 Free PMC article. - The dose-dependent effect of the D2R agonist quinpirole microinjected into the ventral pallidum on information flow in the limbic system.
Peczely L, Grace AA. Peczely L, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111059. doi: 10.1016/j.pnpbp.2024.111059. Epub 2024 Jun 18. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38901759 - Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.
Sias AC, Jafar Y, Goodpaster CM, Ramírez-Armenta K, Wrenn TM, Griffin NK, Patel K, Lamparelli AC, Sharpe MJ, Wassum KM. Sias AC, et al. Nat Neurosci. 2024 Apr;27(4):728-736. doi: 10.1038/s41593-024-01586-7. Epub 2024 Feb 23. Nat Neurosci. 2024. PMID: 38396258 Free PMC article. - The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.
Sepahvand T, Power KD, Qin T, Yuan Q. Sepahvand T, et al. Biology (Basel). 2023 Sep 22;12(10):1274. doi: 10.3390/biology12101274. Biology (Basel). 2023. PMID: 37886984 Free PMC article. Review. - Functional neuroanatomy of monoaminergic systems in the basolateral nuclear complex of the amygdala: Neuronal targets, receptors, and circuits.
McDonald AJ. McDonald AJ. J Neurosci Res. 2023 Sep;101(9):1409-1432. doi: 10.1002/jnr.25201. Epub 2023 May 11. J Neurosci Res. 2023. PMID: 37166098 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous