Oestrogen receptor beta in breast cancer: good, bad or still too early to tell? - PubMed (original) (raw)
Review
Oestrogen receptor beta in breast cancer: good, bad or still too early to tell?
Valerie Speirs. J Pathol. 2002 Jun.
Abstract
Two oestrogen receptors (ERs), ER alpha and ER beta, have been identified. ER alpha is by far the better characterized and is an established predictive marker in breast cancer which influences decisions on whether or not to give adjuvant anti-oestrogens, such as tamoxifen. In contrast, the function of ER beta in breast pathobiology is unclear, partly because most studies have focused on its mRNA rather than the protein. In this review, the significance of ER beta in the human breast is reviewed with respect to recent literature and its possible implications are discussed.
Copyright 2002 John Wiley & Sons, Ltd.
Similar articles
- Oestrogen receptors alpha and beta show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer.
Borgquist S, Holm C, Stendahl M, Anagnostaki L, Landberg G, Jirström K. Borgquist S, et al. J Clin Pathol. 2008 Feb;61(2):197-203. doi: 10.1136/jcp.2006.040378. J Clin Pathol. 2008. PMID: 18223096 - Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications.
Badve S, Nakshatri H. Badve S, et al. J Clin Pathol. 2009 Jan;62(1):6-12. doi: 10.1136/jcp.2008.059899. Epub 2008 Sep 15. J Clin Pathol. 2009. PMID: 18794199 Review. - Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial.
Pentheroudakis G, Kalogeras KT, Wirtz RM, Grimani I, Zografos G, Gogas H, Stropp U, Pectasides D, Skarlos D, Hennig G, Samantas E, Bafaloukos D, Papakostas P, Kalofonos HP, Pavlidis N, Fountzilas G. Pentheroudakis G, et al. Breast Cancer Res Treat. 2009 Jul;116(1):131-43. doi: 10.1007/s10549-008-0144-9. Epub 2008 Jul 31. Breast Cancer Res Treat. 2009. PMID: 18668363 Clinical Trial. - Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer.
Hopp TA, Weiss HL, Parra IS, Cui Y, Osborne CK, Fuqua SA. Hopp TA, et al. Clin Cancer Res. 2004 Nov 15;10(22):7490-9. doi: 10.1158/1078-0432.CCR-04-1114. Clin Cancer Res. 2004. PMID: 15569979 - Molecular analysis of hormone receptor positive (luminal) breast cancers: what have we learnt?
Loi S. Loi S. Eur J Cancer. 2008 Dec;44(18):2813-8. doi: 10.1016/j.ejca.2008.09.012. Epub 2008 Nov 5. Eur J Cancer. 2008. PMID: 18990560 Review.
Cited by
- Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective.
Hernando C, Ortega-Morillo B, Tapia M, Moragón S, Martínez MT, Eroles P, Garrido-Cano I, Adam-Artigues A, Lluch A, Bermejo B, Cejalvo JM. Hernando C, et al. Int J Mol Sci. 2021 Jul 22;22(15):7812. doi: 10.3390/ijms22157812. Int J Mol Sci. 2021. PMID: 34360578 Free PMC article. Review. - Risk of breast cancer in women after a salivary gland carcinoma or pleomorphic adenoma in the Netherlands.
Valstar MH, Schaapveld M, van den Broek EC, van Velthuysen MF, de Ridder M, Schmidt MK, van Dijk BAC, Balm AJM, Smeele LE. Valstar MH, et al. Cancer Med. 2021 Jan;10(1):424-434. doi: 10.1002/cam4.3598. Epub 2020 Nov 28. Cancer Med. 2021. PMID: 33247629 Free PMC article. - Update on the therapeutic significance of estrogen receptor beta in malignant gliomas.
Lan YL, Zou S, Wang X, Lou JC, Xing JS, Yu M, Zhang B. Lan YL, et al. Oncotarget. 2017 Sep 18;8(46):81686-81696. doi: 10.18632/oncotarget.20970. eCollection 2017 Oct 6. Oncotarget. 2017. PMID: 29113424 Free PMC article. Review. - Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas.
Dueñas Jiménez JM, Candanedo Arellano A, Santerre A, Orozco Suárez S, Sandoval Sánchez H, Feria Romero I, López-Elizalde R, Alonso Venegas M, Netel B, de la Torre Valdovinos B, Dueñas Jiménez SH. Dueñas Jiménez JM, et al. J Neurooncol. 2014 Sep;119(2):275-84. doi: 10.1007/s11060-014-1509-z. Epub 2014 Jul 9. J Neurooncol. 2014. PMID: 25005528 - Gene expression markers in circulating tumor cells may predict bone metastasis and response to hormonal treatment in breast cancer.
Wang H, Molina J, Jiang J, Ferber M, Pruthi S, Jatkoe T, Derecho C, Rajpurohit Y, Zheng J, Wang Y. Wang H, et al. Mol Clin Oncol. 2013 Nov;1(6):1031-1038. doi: 10.3892/mco.2013.163. Epub 2013 Aug 2. Mol Clin Oncol. 2013. PMID: 24649289 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials