Induction and suppression of RNA silencing by an animal virus - PubMed (original) (raw)

. 2002 May 17;296(5571):1319-21.

doi: 10.1126/science.1070948.

Affiliations

• PMID: 12016316
• DOI: 10.1126/science.1070948

Induction and suppression of RNA silencing by an animal virus

Hongwei Li et al. Science. 2002.

Abstract

RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.

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