Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair - PubMed (original) (raw)

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Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair

Christina A Mitchell et al. IUBMB Life. 2002 Jan.

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Abstract

Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.

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