Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen - PubMed (original) (raw)
Comparative Study
. 2002 Jun 1;168(11):5737-45.
doi: 10.4049/jimmunol.168.11.5737.
Affiliations
- PMID: 12023374
- DOI: 10.4049/jimmunol.168.11.5737
Comparative Study
Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen
Renu Dudani et al. J Immunol. 2002.
Abstract
We evaluated CD8(+) T cell responses against the dominant CTL epitope, OVA(257-264), expressed by an acute (Listeria monocytogenes (LM) OVA) vs a chronic pathogen (Mycobacterium bovis bacillus Calmette-Guérin (BCG) OVA) to reveal the influence on CD8(+) T cell memory and consequent protection against a challenge with OVA-expressing tumor cells. Infection with lower doses of both pathogens resulted in stronger bacterial growth but weaker T cell memory indicating that memory correlates with pathogen dose but not with bacterial expansion. The CD8(+) T cell response induced by LM-OVA was helper T cell-independent and was characterized by a rapid effector response followed by a rapid, but massive, attrition. In contrast, BCG-OVA induced a delayed and weak response that was compensated for by a longer effector phase and reduced attrition. This response was partly dependent on CD4(+) T cells. CD8(+) T cell response induced by BCG-OVA, but not LM-OVA, was highly dependent on pathogen persistence to compensate for the weak initial CD8(+) T cell priming. Despite a stronger initial T cell response with LM-OVA, BCG-OVA provided more effective tumor (B16OVA) control at both local and distal sites due to the induction of a persistently activated acquired, and a more potent innate, immunity.
Similar articles
- Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes.
van Faassen H, Dudani R, Krishnan L, Sad S. van Faassen H, et al. J Immunol. 2004 Mar 15;172(6):3491-500. doi: 10.4049/jimmunol.172.6.3491. J Immunol. 2004. PMID: 15004149 - A reduced antigen load in vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guérin).
Russell MS, Iskandar M, Mykytczuk OL, Nash JH, Krishnan L, Sad S. Russell MS, et al. J Immunol. 2007 Jul 1;179(1):211-20. doi: 10.4049/jimmunol.179.1.211. J Immunol. 2007. PMID: 17579040 Free PMC article. - Reducing the stimulation of CD8+ T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset.
van Faassen H, Saldanha M, Gilbertson D, Dudani R, Krishnan L, Sad S. van Faassen H, et al. J Immunol. 2005 May 1;174(9):5341-50. doi: 10.4049/jimmunol.174.9.5341. J Immunol. 2005. PMID: 15843531 - Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses.
Khan SH, Badovinac VP. Khan SH, et al. Semin Immunopathol. 2015 May;37(3):301-10. doi: 10.1007/s00281-015-0477-5. Epub 2015 Apr 10. Semin Immunopathol. 2015. PMID: 25860798 Free PMC article. Review. - Probing CD8 T cell responses with Listeria monocytogenes infection.
Condotta SA, Richer MJ, Badovinac VP, Harty JT. Condotta SA, et al. Adv Immunol. 2012;113:51-80. doi: 10.1016/B978-0-12-394590-7.00005-1. Adv Immunol. 2012. PMID: 22244579 Review.
Cited by
- Long-Lasting, Fine-Tuned Anti-Tumor Activity of Recombinant Listeria monocytogenes Vaccine Is Controlled by Pyroptosis and Necroptosis Regulatory and Effector Molecules.
Olagunju AS, Sardinha AVD, Amarante-Mendes GP. Olagunju AS, et al. Pathogens. 2024 Sep 25;13(10):828. doi: 10.3390/pathogens13100828. Pathogens. 2024. PMID: 39452700 Free PMC article. - XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.
Thakker P, Ariana A, Hajjar S, Cai D, Rijal D, Sad S. Thakker P, et al. PLoS Pathog. 2023 Jun 22;19(6):e1011455. doi: 10.1371/journal.ppat.1011455. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37347786 Free PMC article. - Promotion of CTL epitope presentation by a nanoparticle with environment-responsive stability and phagolysosomal escape capacity.
Dong S, Subramanian S, Parent KN, Chen M. Dong S, et al. J Control Release. 2020 Dec 10;328:653-664. doi: 10.1016/j.jconrel.2020.09.033. Epub 2020 Sep 19. J Control Release. 2020. PMID: 32961248 Free PMC article. - RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Rana A, de Almeida FC, Paico Montero HA, Gonzales Carazas MM, Bortoluci KR, Sad S, Amarante-Mendes GP. Rana A, et al. Front Immunol. 2020 Apr 9;11:536. doi: 10.3389/fimmu.2020.00536. eCollection 2020. Front Immunol. 2020. PMID: 32328060 Free PMC article. - Memory T cell-mediated rejection is mitigated by FcγRIIB expression on CD8+ T cells.
Morris AB, Pinelli DF, Liu D, Wagener M, Ford ML. Morris AB, et al. Am J Transplant. 2020 Aug;20(8):2206-2215. doi: 10.1111/ajt.15837. Epub 2020 Mar 24. Am J Transplant. 2020. PMID: 32154641 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials