Disruption of adiponectin causes insulin resistance and neointimal formation - PubMed (original) (raw)

. 2002 Jul 19;277(29):25863-6.

doi: 10.1074/jbc.C200251200. Epub 2002 May 24.

Yasuo Terauchi, Toshimasa Yamauchi, Tetsuya Kubota, Masao Moroi, Junji Matsui, Kazuhiro Eto, Tokuyuki Yamashita, Junji Kamon, Hidemi Satoh, Wataru Yano, Philippe Froguel, Ryozo Nagai, Satoshi Kimura, Takashi Kadowaki, Tetsuo Noda

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Disruption of adiponectin causes insulin resistance and neointimal formation

Naoto Kubota et al. J Biol Chem. 2002.

Free article

Abstract

The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putative antiatherogenic properties in vitro. In this study we generated adiponectin-deficient mice to directly investigate whether adiponectin has a physiological protective role against diabetes and atherosclerosis in vivo. Heterozygous adiponectin-deficient (adipo(+/-)) mice showed mild insulin resistance, while homozygous adiponectin-deficient (adipo(-/-)) mice showed moderate insulin resistance with glucose intolerance despite body weight gain similar to that of wild-type mice. Moreover, adipo(-/-) mice showed 2-fold more neointimal formation in response to external vascular cuff injury than wild-type mice (p = 0.01). This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo.

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