The SCF ubiquitin ligase: an extended look - PubMed (original) (raw)
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The SCF ubiquitin ligase: an extended look
Peter K Jackson et al. Mol Cell. 2002 May.
Free article
Abstract
The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein. A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished.
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