Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP - PubMed (original) (raw)

doi: 10.1038/ni805. Epub 2002 Jun 10.

Pedro A Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma, Kathleen Smith, Daniel Gorman, Sandra Zurawski, Jon Abrams, Satish Menon, Terri McClanahan, Rene de Waal-Malefyt Rd, Fernando Bazan, Robert A Kastelein, Yong-Jun Liu

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Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP

Vassili Soumelis et al. Nat Immunol. 2002 Jul.

Abstract

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.

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