Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells - PubMed (original) (raw)

doi: 10.1038/ni812. Epub 2002 Jun 17.

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• PMID: 12068292
• DOI: 10.1038/ni812

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells

Jason Gill et al. Nat Immunol. 2002 Jul.

Abstract

The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages. Here we characterized a thymic epithelial cell subpopulation identified by the cell surface glycoprotein MTS24. These cells contained epithelial progenitor cells that were competent and sufficient to fully reconstitute the complex thymic epithelial microenvironment that supported normal T cell development.

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• Thymus by numbers.
  Petrie HT, Van Ewijk W. Petrie HT, et al. Nat Immunol. 2002 Jul;3(7):604-5. doi: 10.1038/ni0702-604. Nat Immunol. 2002. PMID: 12087415 No abstract available.

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