The neural basis of mood-congruent processing biases in depression - PubMed (original) (raw)
Comparative Study
. 2002 Jul;59(7):597-604.
doi: 10.1001/archpsyc.59.7.597.
Affiliations
- PMID: 12090812
- DOI: 10.1001/archpsyc.59.7.597
Comparative Study
The neural basis of mood-congruent processing biases in depression
Rebecca Elliott et al. Arch Gen Psychiatry. 2002 Jul.
Abstract
Background: Mood-congruent processing biases are among the most robust research findings in neuropsychological studies of depression. Depressed patients show preferential processing of negatively toned stimuli across a range of cognitive tasks. The present study aimed to determine whether these behavioral abnormalities are associated with specific neural substrates.
Methods: Ten depressed patients and 11 healthy control subjects underwent scanning during performance of an emotional go/no-go task using functional magnetic resonance imaging. The task allowed comparison among neural response to happy, sad, and neutral words, in the context of these words as targets (ie, stimuli to which subjects were required to make a motor response) or distractors (ie, stimuli to which the motor response was withheld).
Results: Depressed patients showed attenuated neural responses to emotional relative to neutral targets in ventral cingulate and posterior orbitofrontal cortices. However, patients showed elevated responses specific to sad targets in rostral anterior cingulate extending to anterior medial prefrontal cortex. Unlike controls, patients showed differential neural response to emotional, particularly sad, distractors in the lateral orbitofrontal cortex.
Conclusions: These findings suggest a distinct neural substrate for mood-congruent processing biases in performance. The medial and orbital prefrontal regions may play a key role in mediating the interaction between mood and cognition in affective disorder.
Similar articles
- Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study.
Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ. Elliott R, et al. Neuroreport. 2000 Jun 5;11(8):1739-44. doi: 10.1097/00001756-200006050-00028. Neuroreport. 2000. PMID: 10852235 - A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices.
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. Blumberg HP, et al. Arch Gen Psychiatry. 2003 Jun;60(6):601-9. doi: 10.1001/archpsyc.60.6.601. Arch Gen Psychiatry. 2003. PMID: 12796223 - Neural correlates of attention biases of people with major depressive disorder: a voxel-based morphometric study.
Leung KK, Lee TM, Wong MM, Li LS, Yip PS, Khong PL. Leung KK, et al. Psychol Med. 2009 Jul;39(7):1097-106. doi: 10.1017/S0033291708004546. Epub 2008 Oct 23. Psychol Med. 2009. PMID: 18945378 - Neural Circuitry of Impaired Emotion Regulation in Substance Use Disorders.
Wilcox CE, Pommy JM, Adinoff B. Wilcox CE, et al. Am J Psychiatry. 2016 Apr 1;173(4):344-61. doi: 10.1176/appi.ajp.2015.15060710. Epub 2016 Jan 15. Am J Psychiatry. 2016. PMID: 26771738 Free PMC article. Review. - Functional neuroimaging studies of human emotions.
Phan KL, Wager TD, Taylor SF, Liberzon I. Phan KL, et al. CNS Spectr. 2004 Apr;9(4):258-66. doi: 10.1017/s1092852900009196. CNS Spectr. 2004. PMID: 15048050 Review.
Cited by
- Engram mechanisms of memory linking and identity.
Choucry A, Nomoto M, Inokuchi K. Choucry A, et al. Nat Rev Neurosci. 2024 Jun;25(6):375-392. doi: 10.1038/s41583-024-00814-0. Epub 2024 Apr 25. Nat Rev Neurosci. 2024. PMID: 38664582 Review. - Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study.
Armand S, Langley C, Johansen A, Ozenne B, Overgaard-Hansen O, Larsen K, Jensen PS, Knudsen GM, Sahakian BJ, Stenbæk DS, Fisher PM. Armand S, et al. Sci Rep. 2024 Feb 7;14(1):3149. doi: 10.1038/s41598-024-51448-2. Sci Rep. 2024. PMID: 38326352 Free PMC article. Clinical Trial. - Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment.
Zhang B, Rolls ET, Wang X, Xie C, Cheng W, Feng J. Zhang B, et al. Mol Psychiatry. 2024 Apr;29(4):914-928. doi: 10.1038/s41380-023-02380-w. Epub 2024 Jan 12. Mol Psychiatry. 2024. PMID: 38212376 Review. - Aperiodic neural activity is a biomarker for depression severity.
Hacker C, Mocchi MM, Xiao J, Metzger BA, Adkinson JA, Pascuzzi BR, Mathura RC, Oswalt D, Watrous A, Bartoli E, Allawala A, Pirtle V, Fan X, Danstrom I, Shofty B, Banks G, Zhang Y, Armenta-Salas M, Mirpour K, Provenza N, Mathew S, Cohn J, Borton D, Goodman W, Pouratian N, Sheth SA, Bijanki KR. Hacker C, et al. medRxiv [Preprint]. 2023 Nov 8:2023.11.07.23298040. doi: 10.1101/2023.11.07.23298040. medRxiv. 2023. PMID: 37986996 Free PMC article. Preprint. - Classification of bipolar disorders using the multilayer modularity in dynamic minimum spanning tree from resting state fMRI.
Wang H, Zhu R, Tian S, Shao J, Dai Z, Xue L, Sun Y, Chen Z, Yao Z, Lu Q. Wang H, et al. Cogn Neurodyn. 2023 Dec;17(6):1609-1619. doi: 10.1007/s11571-022-09907-x. Epub 2022 Dec 3. Cogn Neurodyn. 2023. PMID: 37974586
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources