Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung - PubMed (original) (raw)
. 2002 Jul 1;62(13):3659-62.
Affiliations
- PMID: 12097271
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
Montserrat Sanchez-Cespedes et al. Cancer Res. 2002.
Abstract
Frequent losses of chromosome 19p have recently been observed in sporadic lung adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped in the minimal-deleted region. Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors. We detected a high frequency of somatic alterations (mainly nonsense mutations) in primary lung adenocarcinomas and in lung cancer cell lines. Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.
Similar articles
- BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer.
Rodriguez-Nieto S, Sanchez-Cespedes M. Rodriguez-Nieto S, et al. Carcinogenesis. 2009 Apr;30(4):547-54. doi: 10.1093/carcin/bgp035. Epub 2009 Jan 28. Carcinogenesis. 2009. PMID: 19176640 Review. - Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene.
Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M. Carretero J, et al. Oncogene. 2004 May 13;23(22):4037-40. doi: 10.1038/sj.onc.1207502. Oncogene. 2004. PMID: 15021901 - Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Fernandez P, Carretero J, Medina PP, Jimenez AI, Rodriguez-Perales S, Paz MF, Cigudosa JC, Esteller M, Lombardia L, Morente M, Sanchez-Verde L, Sotelo T, Sanchez-Cespedes M. Fernandez P, et al. Oncogene. 2004 Jun 24;23(29):5084-91. doi: 10.1038/sj.onc.1207665. Oncogene. 2004. PMID: 15077168 - Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
Wang ZJ, Churchman M, Campbell IG, Xu WH, Yan ZY, McCluggage WG, Foulkes WD, Tomlinson IP. Wang ZJ, et al. Br J Cancer. 1999 Apr;80(1-2):70-2. doi: 10.1038/sj.bjc.6690323. Br J Cancer. 1999. PMID: 10389980 Free PMC article. - Mutations in the human LKB1/STK11 gene.
Launonen V. Launonen V. Hum Mutat. 2005 Oct;26(4):291-7. doi: 10.1002/humu.20222. Hum Mutat. 2005. PMID: 16110486 Review.
Cited by
- Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer.
Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M. Ghazi PC, et al. Elife. 2024 Aug 30;13:RP96992. doi: 10.7554/eLife.96992. Elife. 2024. PMID: 39213022 Free PMC article. - The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions.
Rina A, Maffeo D, Minnai F, Esposito M, Palmieri M, Serio VB, Rosati D, Mari F, Frullanti E, Colombo F. Rina A, et al. Cancers (Basel). 2024 Aug 19;16(16):2882. doi: 10.3390/cancers16162882. Cancers (Basel). 2024. PMID: 39199653 Free PMC article. Review. - LKB1 suppresses KSHV reactivation and promotes primary effusion lymphoma progression.
Li G, Li Y, Tang X, Wang L, Yue S, He S, Li T. Li G, et al. J Virol. 2024 Sep 17;98(9):e0060424. doi: 10.1128/jvi.00604-24. Epub 2024 Aug 28. J Virol. 2024. PMID: 39194241 - Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway.
Wei X, Liu Q, Liu L, Wang D, Liu J, Zhu Q, Xu Z, Chen Q, Xu W. Wei X, et al. Int J Mol Sci. 2024 Jul 21;25(14):7973. doi: 10.3390/ijms25147973. Int J Mol Sci. 2024. PMID: 39063214 Free PMC article. - Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance.
Dou Y, Zheng J, Kang J, Wang L, Huang D, Liu Y, He C, Lin C, Lu C, Wu D, Han R, Li L, Tang L, He Y. Dou Y, et al. iScience. 2024 May 30;27(7):110150. doi: 10.1016/j.isci.2024.110150. eCollection 2024 Jul 19. iScience. 2024. PMID: 39040065 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Molecular Biology Databases