Lack of common NOD2 variants in Japanese patients with Crohn's disease - PubMed (original) (raw)
doi: 10.1053/gast.2002.34155.
Kazuo Tamura, Yoshitaka Kinouchi, Yoshihiro Fukuda, Seiichi Takahashi, Yasunori Ogura, Naohiro Inohara, Gabriel Núñez, Yusuke Kishi, Yuji Koike, Tooru Shimosegawa, Takashi Shimoyama, Toshifumi Hibi
Affiliations
- PMID: 12105836
- DOI: 10.1053/gast.2002.34155
Lack of common NOD2 variants in Japanese patients with Crohn's disease
Nagamu Inoue et al. Gastroenterology. 2002 Jul.
Abstract
Background & aims: Previous studies have linked Crohn's disease (CD) to the pericentromeric region of chromosome 16 (IBD1). Three independent studies of Western populations have recently shown that 3 variants of NOD2, a gene located at 16q12, are associated with susceptibility to CD. Here, we have evaluated the 3 NOD2 variants in Japanese patients to determine whether the gene is also associated with susceptibility to CD in a non-Western population.
Methods: Blood samples were obtained from 350 patients with CD, 272 patients with ulcerative colitis, and 292 healthy controls at 3 hospitals in Japan. DNA was sequenced in the region of the 3 NOD2 variants (C2104T in exon 4, G2722C in exon 8, and 3020insC in exon 11) by genomic polymerase chain reaction followed by direct sequencing.
Results: Among the subjects in our 3 study groups, including patients with CD, patients with ulcerative colitis, and healthy controls, none had common NOD2 variants that have been associated with CD in white patients.
Conclusions: These results indicate that genetic variation, which may predispose some human populations to CD, may not be present in other populations and specifically that common variants in NOD2 found in white patients with CD are not associated with CD in the Japanese population.
Similar articles
- [Frequency analysis of NOD2 gene mutations in Korean patients with Crohn's disease].
Lee GH, Kim CG, Kim JS, Jung HC, Song IS. Lee GH, et al. Korean J Gastroenterol. 2005 Mar;45(3):162-8. Korean J Gastroenterol. 2005. PMID: 15778542 Korean. - CARD15/NOD2 in a Tunisian population with Crohn's disease.
Zouiten-Mekki L, Zaouali H, Boubaker J, Karoui S, Fekih M, Matri S, Hamzaoui S, Filali A, Chaabouni H, Hugot JP. Zouiten-Mekki L, et al. Dig Dis Sci. 2005 Jan;50(1):130-5. doi: 10.1007/s10620-005-1290-0. Dig Dis Sci. 2005. PMID: 15712650 - Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease.
Yamazaki K, Takazoe M, Tanaka T, Kazumori T, Nakamura Y. Yamazaki K, et al. J Hum Genet. 2002;47(9):469-72. doi: 10.1007/s100380200067. J Hum Genet. 2002. PMID: 12202985 - NOD2/CARD15: relevance in clinical practice.
Vermeire S. Vermeire S. Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):569-75. doi: 10.1016/j.bpg.2003.12.008. Best Pract Res Clin Gastroenterol. 2004. PMID: 15157828 Review. - The Nod2 gene in Crohn's disease: implications for future research into the genetics and immunology of Crohn's disease.
Cho JH. Cho JH. Inflamm Bowel Dis. 2001 Aug;7(3):271-5. doi: 10.1097/00054725-200108000-00014. Inflamm Bowel Dis. 2001. PMID: 11515855 Review.
Cited by
- Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response.
Sato T, Nakai T, Tamura N, Okamoto S, Matsuoka K, Sakuraba A, Fukushima T, Uede T, Hibi T. Sato T, et al. Gut. 2005 Sep;54(9):1254-62. doi: 10.1136/gut.2004.048298. Gut. 2005. PMID: 16099792 Free PMC article. - The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation.
Tattoli I, Travassos LH, Carneiro LA, Magalhaes JG, Girardin SE. Tattoli I, et al. Semin Immunopathol. 2007 Sep;29(3):289-301. doi: 10.1007/s00281-007-0083-2. Epub 2007 Aug 10. Semin Immunopathol. 2007. PMID: 17690884 Review. - The risk of antibiotics and enterocolitis for the development of inflammatory bowel disease: a Japanese administrative database analysis.
Shimodaira Y, Watanabe K, Iijima K. Shimodaira Y, et al. Sci Rep. 2022 May 9;12(1):7604. doi: 10.1038/s41598-022-11646-2. Sci Rep. 2022. PMID: 35534662 Free PMC article. - Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in different populations.
Papa A, Danese S, Armuzzi A, Gaetani E, Flex A, Pola P, Gasbarrini A. Papa A, et al. Gut. 2003 Aug;52(8):1227-8; author reply 1228. doi: 10.1136/gut.52.8.1227-b. Gut. 2003. PMID: 12865290 Free PMC article. No abstract available. - Human defensins and LL-37 in mucosal immunity.
Doss M, White MR, Tecle T, Hartshorn KL. Doss M, et al. J Leukoc Biol. 2010 Jan;87(1):79-92. doi: 10.1189/jlb.0609382. Epub 2009 Oct 6. J Leukoc Biol. 2010. PMID: 19808939 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases