Neural stem cells - PubMed (original) (raw)
. 2002 Jul;197(4):536-50.
doi: 10.1002/path.1189.
Affiliations
- PMID: 12115869
- DOI: 10.1002/path.1189
Neural stem cells
Nigel L Kennea et al. J Pathol. 2002 Jul.
Abstract
Neural stem cells (NSCs) have the ability to self-renew, and are capable of differentiating into neurones, astrocytes and oligodendrocytes. Such cells have been isolated from the developing brain and more recently from the adult central nervous system. This review aims to provide an overview of the current research in this evolving area. There is now increasing knowledge of the factors controlling the division and differentiation of NSCs during normal brain development. In addition, the cues for differentiation in vitro, and the possibility of transdifferentiation are reviewed. The discovery of these cells in the adult brain has encouraged research into their role during neurogenesis in the normal mature brain and after injury. Lastly other sources of neural precursors are discussed, and the potential for stem cells to be used in cell replacement therapy for brain injury or degenerative brain diseases with a particular emphasis on cerebral ischaemia and Parkinson's disease.
Copyright 2002 John Wiley & Sons, Ltd.
Similar articles
- Glial influences on neural stem cell development: cellular niches for adult neurogenesis.
Ma DK, Ming GL, Song H. Ma DK, et al. Curr Opin Neurobiol. 2005 Oct;15(5):514-20. doi: 10.1016/j.conb.2005.08.003. Curr Opin Neurobiol. 2005. PMID: 16144763 Review. - Neural precursor cells: applications for the study and repair of the central nervous system.
Fisher LJ. Fisher LJ. Neurobiol Dis. 1997;4(1):1-22. doi: 10.1006/nbdi.1997.0137. Neurobiol Dis. 1997. PMID: 9258907 Review. - Multipotent stem cells in the adult mammalian central nervous system.
Woźniak W. Woźniak W. Folia Morphol (Warsz). 1999;58(3 Suppl 2):57-63. Folia Morphol (Warsz). 1999. PMID: 10959261 Review. - Neural stem cells, neural progenitors, and neurotrophic factors.
Hsu YC, Lee DC, Chiu IM. Hsu YC, et al. Cell Transplant. 2007;16(2):133-50. Cell Transplant. 2007. PMID: 17474295 Review. - Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics.
Trujillo CA, Schwindt TT, Martins AH, Alves JM, Mello LE, Ulrich H. Trujillo CA, et al. Cytometry A. 2009 Jan;75(1):38-53. doi: 10.1002/cyto.a.20666. Cytometry A. 2009. PMID: 18988295 Review.
Cited by
- Human umbilical cord blood stem cells: rational for use as a neuroprotectant in ischemic brain disease.
Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Arien-Zakay H, et al. Int J Mol Sci. 2010 Sep 21;11(9):3513-28. doi: 10.3390/ijms11093513. Int J Mol Sci. 2010. PMID: 20957109 Free PMC article. Review. - Severe Hypoxia: Consequences to Neural Stem Cells and Neurons.
Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. Felfly H, et al. J Neurol Res. 2011;1(5):10.4021/jnr70w. doi: 10.4021/jnr70w. J Neurol Res. 2011. PMID: 24348887 Free PMC article. - Stem cells in microfluidics.
Wu HW, Lin CC, Lee GB. Wu HW, et al. Biomicrofluidics. 2011 Mar 30;5(1):13401. doi: 10.1063/1.3528299. Biomicrofluidics. 2011. PMID: 21522491 Free PMC article. - MicroRNAs, Stem Cells in Bipolar Disorder, and Lithium Therapeutic Approach.
Coradduzza D, Garroni G, Congiargiu A, Balzano F, Cruciani S, Sedda S, Nivoli A, Maioli M. Coradduzza D, et al. Int J Mol Sci. 2022 Sep 10;23(18):10489. doi: 10.3390/ijms231810489. Int J Mol Sci. 2022. PMID: 36142403 Free PMC article. Review. - Brain injury and neural stem cells.
Ludwig PE, Thankam FG, Patil AA, Chamczuk AJ, Agrawal DK. Ludwig PE, et al. Neural Regen Res. 2018 Jan;13(1):7-18. doi: 10.4103/1673-5374.224361. Neural Regen Res. 2018. PMID: 29451199 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical