Bacteriophage control of bacterial virulence - PubMed (original) (raw)

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Bacteriophage control of bacterial virulence

Patrick L Wagner et al. Infect Immun. 2002 Aug.

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FIG. 1.

FIG. 1.

Phage control of Stx production and release by E. coli. (Top) A partial map (not to scale) of an integrated Stx-encoding prophage is shown. Transcription from phage promoters is limited both by direct phage repressor activity at _p_L and _p_R and by transcriptional terminators (downstream of _p_L, _p_R, and _p_R′). Following prophage induction, repressor cleavage allows for increased transcription from _p_L and _p_R and production of antiterminators N and Q. These proteins facilitate transcription initiated at _p_R and _p_R′, respectively, by allowing readthrough at several terminators, including _t_L, _t_R1, and _t_R′. (Bottom) Both the _p_R and _p_R′ promoters, as well as the toxin-associated promoter (_p_Stx) can contribute directly to stx transcription following prophage induction. Additionally, the phage replication gene products (O and P) contribute to Stx production by amplifying stx copy numbers. The phage lysis gene products set a limit on the duration of Stx production and provide a mechanism of toxin release from the cell (97).

References

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