IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells - PubMed (original) (raw)
doi: 10.1016/s1074-7613(02)00324-2.
Jackie C Timans, Jeanne Cheung, Rency Rosales, Holger Kanzler, Jonathan Gilbert, Linda Hibbert, Tatyana Churakova, Marilyn Travis, Elena Vaisberg, Wendy M Blumenschein, Jeanine D Mattson, Janet L Wagner, Wayne To, Sandra Zurawski, Terrill K McClanahan, Daniel M Gorman, J Fernando Bazan, Rene de Waal Malefyt, Donna Rennick, Robert A Kastelein
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- PMID: 12121660
- DOI: 10.1016/s1074-7613(02)00324-2
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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
Stefan Pflanz et al. Immunity. 2002 Jun.
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Abstract
An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.
Comment in
- Further checkpoints in Th1 development.
Robinson DS, O'Garra A. Robinson DS, et al. Immunity. 2002 Jun;16(6):755-8. doi: 10.1016/s1074-7613(02)00331-x. Immunity. 2002. PMID: 12121657 Review.
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