Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure - PubMed (original) (raw)
Multicenter Study
. 2002 Jul 18;347(3):161-7.
doi: 10.1056/NEJMoa020233.
Padma Krishnaswamy, Richard M Nowak, James McCord, Judd E Hollander, Philippe Duc, Torbjørn Omland, Alan B Storrow, William T Abraham, Alan H B Wu, Paul Clopton, Philippe G Steg, Arne Westheim, Catherine Wold Knudsen, Alberto Perez, Radmila Kazanegra, Howard C Herrmann, Peter A McCullough; Breathing Not Properly Multinational Study Investigators
Affiliations
- PMID: 12124404
- DOI: 10.1056/NEJMoa020233
Free article
Multicenter Study
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
Alan S Maisel et al. N Engl J Med. 2002.
Free article
Abstract
Background: B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension.
Methods: We conducted a prospective study of 1586 patients who came to the emergency department with acute dyspnea and whose B-type natriuretic peptide was measured with a bedside assay. The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists, who were blinded to the results of the B-type natriuretic peptide assay.
Results: The final diagnosis was dyspnea due to congestive heart failure in 744 patients (47 percent), dyspnea due to noncardiac causes in 72 patients with a history of left ventricular dysfunction (5 percent), and no finding of congestive heart failure in 770 patients (49 percent). B-type natriuretic peptide levels by themselves were more accurate than any historical or physical findings or laboratory values in identifying congestive heart failure as the cause of dyspnea. The diagnostic accuracy of B-type natriuretic peptide at a cutoff of 100 pg per milliliter was 83.4 percent. The negative predictive value of B-type natriuretic peptide at levels of less than 50 pg per milliliter was 96 percent. In multiple logistic-regression analysis, measurements of B-type natriuretic peptide added significant independent predictive power to other clinical variables in models predicting which patients had congestive heart failure.
Conclusions: Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
Copyright 2002 Massachusetts Medical Society.
Comment in
- B-type natriuretic peptide -- a window to the heart.
Baughman KL. Baughman KL. N Engl J Med. 2002 Jul 18;347(3):158-9. doi: 10.1056/NEJMp020057. N Engl J Med. 2002. PMID: 12124403 No abstract available. - B-type natriuretic peptide in heart failure.
Colli A, Fraquelli M, Conte D. Colli A, et al. N Engl J Med. 2002 Dec 12;347(24):1976-8; author reply 1976-8. doi: 10.1056/NEJM200212123472415. N Engl J Med. 2002. PMID: 12477952 No abstract available. - B-type natriuretic peptide in heart failure.
Hassan Y, Shapira AR, Hassan S. Hassan Y, et al. N Engl J Med. 2002 Dec 12;347(24):1976-8; author reply 1976-8. N Engl J Med. 2002. PMID: 12479192 No abstract available. - B-type natriuretic peptide in heart failure.
Foote RS, Pearlman JD. Foote RS, et al. N Engl J Med. 2002 Dec 12;347(24):1976-8; author reply 1976-8. N Engl J Med. 2002. PMID: 12479193 No abstract available. - B-type natriuretic peptide in the diagnosis of heart failure.
Meyer TE. Meyer TE. Curr Cardiol Rep. 2003 May;5(3):214-5. Curr Cardiol Rep. 2003. PMID: 12691639 No abstract available.
Summary for patients in
- B-type natriuretic peptide is an accurate predictor of heart failure in the emergency department.
O'Connor J, Meurer LN. O'Connor J, et al. J Fam Pract. 2002 Oct;51(10):816. J Fam Pract. 2002. PMID: 12401145 No abstract available.
Similar articles
- Impact of the history of congestive heart failure on the utility of B-type natriuretic peptide in the emergency diagnosis of heart failure: results from the Breathing Not Properly Multinational Study.
Strunk A, Bhalla V, Clopton P, Nowak RM, McCord J, Hollander JE, Duc P, Storrow AB, Abraham WT, Wu AH, Steg G, Perez A, Kazanegra R, Herrmann HC, Aumont MC, McCullough PA, Maisel A. Strunk A, et al. Am J Med. 2006 Jan;119(1):69.e1-11. doi: 10.1016/j.amjmed.2005.04.029. Am J Med. 2006. PMID: 16431187 - Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea.
Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud AP. Mueller C, et al. N Engl J Med. 2004 Feb 12;350(7):647-54. doi: 10.1056/NEJMoa031681. N Engl J Med. 2004. PMID: 14960741 Clinical Trial. - Amino-terminal pro-brain natriuretic peptide for the diagnosis of acute heart failure in patients with previous obstructive airway disease.
Tung RH, Camargo CA Jr, Krauser D, Anwaruddin S, Baggish A, Chen A, Januzzi JL Jr. Tung RH, et al. Ann Emerg Med. 2006 Jul;48(1):66-74. doi: 10.1016/j.annemergmed.2005.12.022. Epub 2006 Feb 17. Ann Emerg Med. 2006. PMID: 16781921 - B-type natriuretic peptide: a diagnostic, prognostic, and therapeutic tool in heart failure.
Prahash A, Lynch T. Prahash A, et al. Am J Crit Care. 2004 Jan;13(1):46-53; quiz 54-5. Am J Crit Care. 2004. PMID: 14735647 Review. - [B-type natriuretic peptide--current use in the diagnosis and management of heart failure].
Müller C, Kuster G, Büttner HJ, Buser P. Müller C, et al. Herz. 2003 Aug;28(5):374-9. doi: 10.1007/s00059-003-2415-x. Herz. 2003. PMID: 12928736 Review. German.
Cited by
- [Chest pains in emergency admission. Diagnostics and treatment].
Hobbach HP, Lemm H, Buerke M. Hobbach HP, et al. Med Klin Intensivmed Notfmed. 2013 Feb;108(1):7-18. doi: 10.1007/s00063-012-0169-z. Epub 2013 Feb 13. Med Klin Intensivmed Notfmed. 2013. PMID: 23400381 Review. German. - High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy.
Everett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S. Everett BM, et al. Circulation. 2015 May 26;131(21):1851-60. doi: 10.1161/CIRCULATIONAHA.114.014522. Epub 2015 Mar 30. Circulation. 2015. PMID: 25825410 Free PMC article. Clinical Trial. - Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study.
Ntsekhe M, Mayosi BM, Gumbo T. Ntsekhe M, et al. Cardiovasc Ultrasound. 2012 Jul 28;10:30. doi: 10.1186/1476-7120-10-30. Cardiovasc Ultrasound. 2012. PMID: 22838492 Free PMC article. - Plasma ProBNP Is Not a Specific Marker for Transient Myocardial Ischemia.
Maqsood K, Shakoor MT, Cook JR, Giugliano GR, Lotfi A. Maqsood K, et al. J Clin Med Res. 2015 Jul;7(7):506-10. doi: 10.14740/jocmr2024w. Epub 2015 May 8. J Clin Med Res. 2015. PMID: 26015814 Free PMC article. - Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.
Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC. Mebazaa A, et al. J Intensive Care. 2016 Mar 31;4:24. doi: 10.1186/s40560-016-0151-6. eCollection 2016. J Intensive Care. 2016. PMID: 27034779 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical