Sleep apnea, APOE4 and Alzheimer's disease 20 years and counting? - PubMed (original) (raw)
Review
Sleep apnea, APOE4 and Alzheimer's disease 20 years and counting?
Donald L Bliwise. J Psychosom Res. 2002 Jul.
Abstract
Alzheimer's disease (AD) is acknowledged to be at least partially genetic, and one of the key genotypic markers for this condition is the APOE4 allele. Links between sleep apnea and AD have long been suspected because of mental impairment seen in some sleep apnea patients and possible evidence suggesting higher rates of sleep apnea in some dementia patients. The recent demonstration of an association between the APOE4 genotype and sleep apnea has rekindled further interest in this topic, particularly because sleep apnea is characterized by multiple genetic vulnerabilities. We review here evidence related to associations between sleep apnea and dementia, the role of APOE4 as a likely marker for cerebrovascular disease, and discuss treatment considerations relevant to sleep apnea as a potentially reversible cause of dementia.
Similar articles
- Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Trial.
Ding X, Kryscio RJ, Turner J, Jicha GA, Cooper G, Caban-Holt A, Schmitt FA, Abner EL. Ding X, et al. J Am Geriatr Soc. 2016 Dec;64(12):2472-2478. doi: 10.1111/jgs.14393. Epub 2016 Nov 1. J Am Geriatr Soc. 2016. PMID: 27801937 Free PMC article. Clinical Trial. - apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene.
Feuk L, Prince JA, Breen G, Emahazion T, Carothers A, St Clair D, Brookes AJ. Feuk L, et al. Hum Genet. 2000 Oct;107(4):391-6. doi: 10.1007/s004390000383. Hum Genet. 2000. PMID: 11129341 - APOE genotype: no influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease.
Aerssens J, Raeymaekers P, Lilienfeld S, Geerts H, Konings F, Parys W. Aerssens J, et al. Dement Geriatr Cogn Disord. 2001 Mar-Apr;12(2):69-77. doi: 10.1159/000051238. Dement Geriatr Cogn Disord. 2001. PMID: 11173877 - Intricate relationship between obstructive sleep apnea and dementia in older adults.
Ercolano E, Bencivenga L, Palaia ME, Carbone G, Scognamiglio F, Rengo G, Femminella GD. Ercolano E, et al. Geroscience. 2024 Feb;46(1):99-111. doi: 10.1007/s11357-023-00958-4. Epub 2023 Oct 9. Geroscience. 2024. PMID: 37814196 Free PMC article. Review. - Diabetes, Alzheimer's disease and apolipoprotein genotype.
Messier C. Messier C. Exp Gerontol. 2003 Sep;38(9):941-6. doi: 10.1016/s0531-5565(03)00153-0. Exp Gerontol. 2003. PMID: 12954480 Review.
Cited by
- Circadian rhythm disturbances in patients with Alzheimer's disease: a review.
Weldemichael DA, Grossberg GT. Weldemichael DA, et al. Int J Alzheimers Dis. 2010 Sep 2;2010:716453. doi: 10.4061/2010/716453. Int J Alzheimers Dis. 2010. PMID: 20862344 Free PMC article. - Recommendations of the Sleep Study Group of the Italian Dementia Research Association (SINDem) on clinical assessment and management of sleep disorders in individuals with mild cognitive impairment and dementia: a clinical review.
Guarnieri B, Musicco M, Caffarra P, Adorni F, Appollonio I, Arnaldi D, Bartoli A, Bonanni E, Bonuccelli U, Caltagirone C, Cerroni G, Concari L, Cosentino FI, Fermi S, Ferri R, Gelosa G, Lombardi G, Mearelli S, Nobili F, Passero S, Perri R, Rocchi R, Sucapane P, Tognoni G, Zabberoni S, Sorbi S. Guarnieri B, et al. Neurol Sci. 2014 Sep;35(9):1329-48. doi: 10.1007/s10072-014-1873-7. Epub 2014 Jul 19. Neurol Sci. 2014. PMID: 25037740 Review. - Pro: Alzheimer's disease and circadian dysfunction: chicken or egg?
Bedrosian TA, Nelson RJ. Bedrosian TA, et al. Alzheimers Res Ther. 2012 Aug 13;4(4):25. doi: 10.1186/alzrt128. eCollection 2012. Alzheimers Res Ther. 2012. PMID: 22883711 Free PMC article. - Course and causes of suspected dementia in young adults: a longitudinal study.
Panegyres PK, Frencham K. Panegyres PK, et al. Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):48-56. doi: 10.1177/1533317506295887. Am J Alzheimers Dis Other Demen. 2007. PMID: 17534002 Free PMC article. - Association of sleep disordered breathing and cognitive deficit in APOE ε4 carriers.
Nikodemova M, Finn L, Mignot E, Salzieder N, Peppard PE. Nikodemova M, et al. Sleep. 2013 Jun 1;36(6):873-80. doi: 10.5665/sleep.2714. Sleep. 2013. PMID: 23729930 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical