TNFalpha-308A associated with shorter intervals of Plasmodium falciparum reinfections - PubMed (original) (raw)
TNFalpha-308A associated with shorter intervals of Plasmodium falciparum reinfections
C G Meyer et al. Tissue Antigens. 2002 Apr.
Abstract
A mutation at position -308 of the tumor necrosis factor alpha (TNF-308A) gene promoter has previously been associated with particular manifestations of infectious and non-infectious diseases. In a longitudinal study on malariological parameters in Gabon, TNF promoter variants of 98 children initially presenting with severe Plasmodium falciparum malaria, followed by a total of 504 reinfection events within 52 months, and 100 children initially presenting with mild malaria followed by a total of 342 reinfections were analyzed. Symptomatic P. falciparum reinfections occurred more quickly (median 11 weeks) in carriers of the TNF-308A allele, with severe malaria at enrollment, compared to carriers of other TNF promoter variants (median 16 weeks). The results show that this particular TNF promoter allele increases the risk of reinfection with the malaria parasite P. falciparum.
Similar articles
- Alleles 308A and 238A in the tumor necrosis factor alpha gene promoter do not increase the risk of severe malaria in children with Plasmodium falciparum infection in Mali.
Cabantous S, Doumbo O, Ranque S, Poudiougou B, Traore A, Hou X, Keita MM, Cisse MB, Dessein AJ, Marquet S. Cabantous S, et al. Infect Immun. 2006 Dec;74(12):7040-2. doi: 10.1128/IAI.01581-05. Epub 2006 Sep 18. Infect Immun. 2006. PMID: 16982833 Free PMC article. - TNF-α promoter polymorphisms (G-238A and G-308A) are associated with susceptibility to Systemic Lupus Erythematosus (SLE) and P. falciparum malaria: a study in malaria endemic area.
Mahto H, Tripathy R, Meher BR, Prusty BK, Sharma M, Deogharia D, Saha AK, Panda AK, Das BK. Mahto H, et al. Sci Rep. 2019 Aug 13;9(1):11752. doi: 10.1038/s41598-019-48182-5. Sci Rep. 2019. PMID: 31409832 Free PMC article. - Malaria blood-stage infection and its control by the immune system.
Perlmann P, Troye-Blomberg M. Perlmann P, et al. Folia Biol (Praha). 2000;46(6):210-8. Folia Biol (Praha). 2000. PMID: 11140853 Review. - Genetic regulation of malaria infection in humans.
Troye-Blomberg M. Troye-Blomberg M. Chem Immunol. 2002;80:243-52. doi: 10.1159/000058847. Chem Immunol. 2002. PMID: 12058642 Review. No abstract available.
Cited by
- Neither the African-Centric S47 Nor P72 Variant of TP53 Is Associated With Reduced Risk of Febrile Malaria in a Malian Cohort Study.
Bhardwaj J, Upadhye A, Gaskin EL, Doumbo S, Kayentao K, Ongoiba A, Traore B, Crompton PD, Tran TM. Bhardwaj J, et al. J Infect Dis. 2023 Jul 14;228(2):202-211. doi: 10.1093/infdis/jiad066. J Infect Dis. 2023. PMID: 36961831 Free PMC article. - Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection.
Ojurongbe O, Funwei RI, Snyder TJ, Farid I, Aziz N, Li Y, Falade CO, Thomas BN. Ojurongbe O, et al. Immunogenetics. 2018 Feb;70(2):135-140. doi: 10.1007/s00251-017-1032-4. Epub 2017 Sep 30. Immunogenetics. 2018. PMID: 28963676 - How malaria has affected the human genome and what human genetics can teach us about malaria.
Kwiatkowski DP. Kwiatkowski DP. Am J Hum Genet. 2005 Aug;77(2):171-92. doi: 10.1086/432519. Epub 2005 Jul 6. Am J Hum Genet. 2005. PMID: 16001361 Free PMC article. Review. - Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study.
Gichohi-Wainaina WN, Melse-Boonstra A, Feskens EJ, Demir AY, Veenemans J, Verhoef H. Gichohi-Wainaina WN, et al. Malar J. 2015 Jun 20;14:249. doi: 10.1186/s12936-015-0767-3. Malar J. 2015. PMID: 26088606 Free PMC article. - Tumor necrosis factor-α (TNF-α) -308G >a promoter polymorphism (rs1800629) promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A meta-analysis.
Kongjam P, Pabalan N, Tharabenjasin P, Jarjanazi H, Chaijaroenkul W, Na-Bangchang K. Kongjam P, et al. PLoS Negl Trop Dis. 2023 Nov 1;17(11):e0011735. doi: 10.1371/journal.pntd.0011735. eCollection 2023 Nov. PLoS Negl Trop Dis. 2023. PMID: 37910577 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources