Endocytosis of lipid rafts: an identity crisis - PubMed (original) (raw)

Review

Endocytosis of lipid rafts: an identity crisis

Pranav Sharma et al. Semin Cell Dev Biol. 2002 Jun.

Abstract

Membrane rafts enriched in cholesterol and sphingolipids have been hypothesized to be key mediators of sorting and signaling functions of associated molecules. Apart from a limited number of biophysical studies in living cell membranes, raft-association has been defined by a simple biochemical criterion, namely the ability to partition with detergent-resistant membranes (DRMs). Here we examine the evidence for the specification of internalization mechanisms and endocytic pathways by rafts as defined by this criterion. We have surveyed the endocytic trafficking of a variety of molecules such as lipids, toxins, glycosylphosphatidylinositol (GPI)-anchored proteins, and DRM-associated transmembrane proteins.

PubMed Disclaimer

Similar articles

• Proteomic analysis of detergent-resistant membranes from Candida albicans.
  Insenser M, Nombela C, Molero G, Gil C. Insenser M, et al. Proteomics. 2006 Apr;6 Suppl 1:S74-81. doi: 10.1002/pmic.200500465. Proteomics. 2006. PMID: 16534748
• Analysis of raft affinity of membrane proteins by detergent-insolubility.
  Brown DA. Brown DA. Methods Mol Biol. 2007;398:9-20. doi: 10.1007/978-1-59745-513-8_2. Methods Mol Biol. 2007. PMID: 18214370
• Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts.
  McIntosh TJ, Vidal A, Simon SA. McIntosh TJ, et al. Biophys J. 2003 Sep;85(3):1656-66. doi: 10.1016/S0006-3495(03)74595-0. Biophys J. 2003. PMID: 12944280 Free PMC article.
• The state of lipid rafts: from model membranes to cells.
  Edidin M. Edidin M. Annu Rev Biophys Biomol Struct. 2003;32:257-83. doi: 10.1146/annurev.biophys.32.110601.142439. Epub 2003 Jan 16. Annu Rev Biophys Biomol Struct. 2003. PMID: 12543707 Review.
• Lipid rafts: signaling and sorting platforms of cells and their roles in cancer.
  Staubach S, Hanisch FG. Staubach S, et al. Expert Rev Proteomics. 2011 Apr;8(2):263-77. doi: 10.1586/epr.11.2. Expert Rev Proteomics. 2011. PMID: 21501018 Review.

Cited by

• Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling.
  Hartung A, Bitton-Worms K, Rechtman MM, Wenzel V, Boergermann JH, Hassel S, Henis YI, Knaus P. Hartung A, et al. Mol Cell Biol. 2006 Oct;26(20):7791-805. doi: 10.1128/MCB.00022-06. Epub 2006 Aug 21. Mol Cell Biol. 2006. PMID: 16923969 Free PMC article.
• The order of rafts. Conference on microdomains, lipid rafts and caveolae.
  Zurzolo C, van Meer G, Mayor S. Zurzolo C, et al. EMBO Rep. 2003 Dec;4(12):1117-21. doi: 10.1038/sj.embor.7400032. Epub 2003 Nov 21. EMBO Rep. 2003. PMID: 14634694 Free PMC article.
• Determination of lipid raft partitioning of fluorescently-tagged probes in living cells by Fluorescence Correlation Spectroscopy (FCS).
  Marquer C, Lévêque-Fort S, Potier MC. Marquer C, et al. J Vis Exp. 2012 Apr 6;(62):e3513. doi: 10.3791/3513. J Vis Exp. 2012. PMID: 22508446 Free PMC article.
• Nanovehicular intracellular delivery systems.
  Prokop A, Davidson JM. Prokop A, et al. J Pharm Sci. 2008 Sep;97(9):3518-90. doi: 10.1002/jps.21270. J Pharm Sci. 2008. PMID: 18200527 Free PMC article. Review.
• Exclusion of a proton ATPase from the apical membrane is associated with cell polarity and tip growth in Nicotiana tabacum pollen tubes.
  Certal AC, Almeida RB, Carvalho LM, Wong E, Moreno N, Michard E, Carneiro J, Rodriguéz-Léon J, Wu HM, Cheung AY, Feijó JA. Certal AC, et al. Plant Cell. 2008 Mar;20(3):614-34. doi: 10.1105/tpc.106.047423. Epub 2008 Mar 25. Plant Cell. 2008. PMID: 18364468 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database