Genetic association studies: design, analysis and interpretation - PubMed (original) (raw)
Review
Genetic association studies: design, analysis and interpretation
Cathryn M Lewis. Brief Bioinform. 2002 Jun.
Abstract
This paper provides a review of the design and analysis of genetic association studies. In case control studies, the different contingency tables and their relationships to the underlying genetic model are defined. Population stratification is discussed, with suggested methods to identify and correct for the effect. The transmission disequilibrium test is provided as an alternative family-based test, which is robust to population stratification. The relative benefits of each analysis are summarised.
Similar articles
- The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification.
Havill LM, Dyer TD, Richardson DK, Mahaney MC, Blangero J. Havill LM, et al. BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S91. doi: 10.1186/1471-2156-6-S1-S91. BMC Genet. 2005. PMID: 16451707 Free PMC article. - Gene Mapping in Admixed Families: A Cautionary Note on the Interpretation of the Transmission Disequilibrium Test and a Possible Solution.
Wang X, Xiao R, Zhu X, Li M. Wang X, et al. Hum Hered. 2016;81(2):106-116. doi: 10.1159/000446956. Epub 2017 Jan 12. Hum Hered. 2016. PMID: 28076865 - ALOX5AP gene and the PDE4D gene in a central European population of stroke patients.
Lõhmussaar E, Gschwendtner A, Mueller JC, Org T, Wichmann E, Hamann G, Meitinger T, Dichgans M. Lõhmussaar E, et al. Stroke. 2005 Apr;36(4):731-6. doi: 10.1161/01.STR.0000157587.59821.87. Epub 2005 Feb 24. Stroke. 2005. PMID: 15731479 - Family-based designs in the age of large-scale gene-association studies.
Laird NM, Lange C. Laird NM, et al. Nat Rev Genet. 2006 May;7(5):385-94. doi: 10.1038/nrg1839. Nat Rev Genet. 2006. PMID: 16619052 Review. - The future of genetic case-control studies.
Schork NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D. Schork NJ, et al. Adv Genet. 2001;42:191-212. doi: 10.1016/s0065-2660(01)42023-2. Adv Genet. 2001. PMID: 11037322 Review.
Cited by
- Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.
Watrowski R, Schuster E, Van Gorp T, Hofstetter G, Fischer MB, Mahner S, Polterauer S, Zeillinger R, Obermayr E. Watrowski R, et al. Int J Mol Sci. 2024 Sep 24;25(19):10272. doi: 10.3390/ijms251910272. Int J Mol Sci. 2024. PMID: 39408600 Free PMC article. - A novel classification framework for genome-wide association study of whole brain MRI images using deep learning.
Yu S, Wu J, Shao Y, Qiu D, Qin ZS; Alzheimer’s Disease Neuroimaging Initiative. Yu S, et al. PLoS Comput Biol. 2024 Oct 15;20(10):e1012527. doi: 10.1371/journal.pcbi.1012527. eCollection 2024 Oct. PLoS Comput Biol. 2024. PMID: 39405331 Free PMC article. - Toll-Like Receptor Genes and Risk of Latent Tuberculosis Infection in People Infected with HIV-1.
Salamaikina S, Kulabukhova E, Korchagin V, Khokhlova O, Mironov K, Akimkin V. Salamaikina S, et al. Viruses. 2024 Aug 28;16(9):1371. doi: 10.3390/v16091371. Viruses. 2024. PMID: 39339847 Free PMC article. - Potential association of SULT2A1 and ABCG2 variant alleles with increased risk for palbociclib toxicity.
Wang C, Hwang M, Paulson B, Mhandire D, Ozair S, O'Connor TL, Gandhi S, Attwood KM, Hertz DL, Goey AK. Wang C, et al. Pharmacogenomics. 2024;25(8-9):367-375. doi: 10.1080/14622416.2024.2380240. Epub 2024 Aug 2. Pharmacogenomics. 2024. PMID: 39092502 - Association of rs4516035 Polymorphism with Osteoporosis in the Southeastern Iranian Population: A Case-Control Study.
Yaghoobi MM, Samare Gholami A. Yaghoobi MM, et al. J Res Health Sci. 2024 Mar 18;24(1):e00603. doi: 10.34172/jrhs.2024.138. Epub 2024 Mar 18. J Res Health Sci. 2024. PMID: 39072539 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources