Brain-tumour drug resistance: the bare essentials - PubMed (original) (raw)
Review
Brain-tumour drug resistance: the bare essentials
Markus Bredel et al. Lancet Oncol. 2002 Jul.
Abstract
Chemotherapy lacks efficacy in most histological types of primary human brain tumours and has, for most types, failed to improve outcome for patients. The unsatisfactory results with chemotherapeutic intervention in these cancers have been chiefly attributed to tumour-cell resistance. This review summarises some of the major molecular markers that, although neither exclusive for nor specific to brain tumours, have been associated with the formation of a chemoresistant phenotype. Elucidation of the cellular mechanisms involved in resistance regulation is needed for future progress in efficient approaches to selective modulation of drug resistance in these lesions.
Similar articles
- Anticancer drug resistance in primary human brain tumors.
Bredel M. Bredel M. Brain Res Brain Res Rev. 2001 Apr;35(2):161-204. doi: 10.1016/s0165-0173(01)00045-5. Brain Res Brain Res Rev. 2001. PMID: 11336781 Review. - Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.
Mathieu A, Remmelink M, D'Haene N, Penant S, Gaussin JF, Van Ginckel R, Darro F, Kiss R, Salmon I. Mathieu A, et al. Cancer. 2004 Oct 15;101(8):1908-18. doi: 10.1002/cncr.20571. Cancer. 2004. PMID: 15386340 - Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.
Tews DS, Nissen A, Külgen C, Gaumann AK. Tews DS, et al. J Neurooncol. 2000 Dec;50(3):227-37. doi: 10.1023/a:1006491405010. J Neurooncol. 2000. PMID: 11263502 - Colon cancer: cancer stem cells markers, drug resistance and treatment.
Kozovska Z, Gabrisova V, Kucerova L. Kozovska Z, et al. Biomed Pharmacother. 2014 Oct;68(8):911-6. doi: 10.1016/j.biopha.2014.10.019. Epub 2014 Oct 30. Biomed Pharmacother. 2014. PMID: 25458789 Review. - Cell Signaling Pathways in Brain Tumors.
Harrison RA, de Groot JF. Harrison RA, et al. Top Magn Reson Imaging. 2017 Feb;26(1):15-26. doi: 10.1097/RMR.0000000000000112. Top Magn Reson Imaging. 2017. PMID: 28079711 Review.
Cited by
- Efficacy of various extent of resection on survival rates of patients with pilocytic astrocytoma: based on a large population.
Su J, Guo S, Chen Z, Han Y, Yan J, Tang Q, Mao Y, Zhang H, Hou G, Dong G, Guo C, Yang P. Su J, et al. Sci Rep. 2024 Oct 20;14(1):24646. doi: 10.1038/s41598-024-75751-0. Sci Rep. 2024. PMID: 39428432 Free PMC article. - In vivo therapy of osteosarcoma using anion transporters-based supramolecular drugs.
Zheng Z, Wei X, Lin Y, Tao S, Li H, Ji Z, Wei H, Jin J, Zhao F, Lang C, Liu J, Chen J. Zheng Z, et al. J Nanobiotechnology. 2024 Jan 13;22(1):29. doi: 10.1186/s12951-023-02270-x. J Nanobiotechnology. 2024. PMID: 38216937 Free PMC article. - Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.
Martinez PJ, Green AL, Borden MA. Martinez PJ, et al. J Control Release. 2024 Jan;365:412-421. doi: 10.1016/j.jconrel.2023.11.037. Epub 2023 Nov 30. J Control Release. 2024. PMID: 38000663 Review. - Multi-Target Neural Differentiation (MTND) Therapeutic Cocktail to Suppress Brain Tumor.
Hu X, Xie J, Yang Y, Qiu Z, Lu W, Lin X, Xu B. Hu X, et al. Int J Mol Sci. 2023 Aug 2;24(15):12329. doi: 10.3390/ijms241512329. Int J Mol Sci. 2023. PMID: 37569705 Free PMC article. - Exosomes Derived from SW480-Resistant Colon Cancer Cells Are Promote Angiogenesis via BMP-2/Smad5 Signaling Pathway.
Yang S, Yao L, Wang X, Sun H, Du C, Song C, Fu J, Wu Y, Huang H, Wang C, Wang Y, Xie Y. Yang S, et al. Appl Bionics Biomech. 2022 May 19;2022:6124374. doi: 10.1155/2022/6124374. eCollection 2022. Appl Bionics Biomech. 2022. PMID: 35634178 Free PMC article. Retracted.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical