Role of integrins in regulating epidermal adhesion, growth and differentiation - PubMed (original) (raw)

Review

Role of integrins in regulating epidermal adhesion, growth and differentiation

Fiona M Watt. EMBO J. 2002.

Abstract

Mammalian epidermis is renewed throughout life by proliferation of a multipotential stem cell population and terminal differentiation of stem cell progeny. In recent years, extracellular matrix receptors of the integrin family have been identified as important regulators of epidermal homeostasis, influencing the balance between stem cell renewal and differentiation. Integrin expression is altered when the epidermis is damaged or diseased, and there is good evidence that specific integrins can contribute positively or negatively to pathogenesis. In this review I summarize what is known about the expression and function of epidermal integrins, and highlight the challenges for future research.

PubMed Disclaimer

Figures

Fig. 1. Schematic representation of how suprabasal integrin expression in the epidermis (A) contributes to the pathogenesis of psoriasis (B) and squamous cell carcinoma (C).

Similar articles

• Stem cell depletion through epidermal deletion of Rac1.
  Benitah SA, Frye M, Glogauer M, Watt FM. Benitah SA, et al. Science. 2005 Aug 5;309(5736):933-5. doi: 10.1126/science.1113579. Science. 2005. PMID: 16081735
• Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation.
  Tennenbaum T, Li L, Belanger AJ, De Luca LM, Yuspa SH. Tennenbaum T, et al. Cell Growth Differ. 1996 May;7(5):615-28. Cell Growth Differ. 1996. PMID: 8732671
• Integrins in regulation of tissue development and function.
  Danen EH, Sonnenberg A. Danen EH, et al. J Pathol. 2003 Dec;201(4):632-41. doi: 10.1002/path.1472. J Pathol. 2003. PMID: 14648669 Review.
• Integrins in regulation of tissue development and function.
  Danen EH, Sonnenberg A. Danen EH, et al. J Pathol. 2003 Jul;200(4):471-80. doi: 10.1002/path.1416. J Pathol. 2003. PMID: 12845614 Corrected and republished. Review.

Cited by

• CLCA splicing isoform associated with adhesion through β1-integrin and its scaffolding protein: specific expression in undifferentiated epithelial cells.
  Yamazaki J, Okamura K, Uehara K, Hatta M. Yamazaki J, et al. J Biol Chem. 2013 Feb 15;288(7):4831-43. doi: 10.1074/jbc.M112.396481. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297403 Free PMC article.
• Diverse epigenetic strategies interact to control epidermal differentiation.
  Mulder KW, Wang X, Escriu C, Ito Y, Schwarz RF, Gillis J, Sirokmány G, Donati G, Uribe-Lewis S, Pavlidis P, Murrell A, Markowetz F, Watt FM. Mulder KW, et al. Nat Cell Biol. 2012 Jun 24;14(7):753-63. doi: 10.1038/ncb2520. Nat Cell Biol. 2012. PMID: 22729083
• Integrin-mediated regulation of epidermal wound functions.
  DiPersio CM, Zheng R, Kenney J, Van De Water L. DiPersio CM, et al. Cell Tissue Res. 2016 Sep;365(3):467-82. doi: 10.1007/s00441-016-2446-2. Epub 2016 Jun 28. Cell Tissue Res. 2016. PMID: 27351421 Free PMC article. Review.
• Alkyloxy carbonyl modified hexapeptides as a high affinity compounds for Wnt5A protein in the treatment of psoriasis.
  Kelotra A, Gokhale SM, Kelotra S, Mukadam V, Nagwanshi K, Bandaru S, Nayarisseri A, Bidwai A. Kelotra A, et al. Bioinformation. 2014 Dec 31;10(12):743-9. doi: 10.6026/97320630010743. eCollection 2014. Bioinformation. 2014. PMID: 25670877 Free PMC article.
• Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function.
  Rix B, Maduro AH, Bridge KS, Grey W. Rix B, et al. Front Physiol. 2022 Sep 30;13:1009160. doi: 10.3389/fphys.2022.1009160. eCollection 2022. Front Physiol. 2022. PMID: 36246104 Free PMC article. Review.

References

1. 1. Adams J.C. and Watt,F.M. (1989) Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature, 340, 307–309. - PubMed
2. 1. Adams J.C. and Watt,F.M. (1991) Expression of β1, β3, β4 and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J. Cell Biol., 115, 829–841. - PMC - PubMed
3. 1. Akiyama M., Smith,L.T. and Shimizu,H. (2000) Changing patterns of localization of putative stem cells in developing human hair follicles. J. Invest. Dermatol., 114, 321–327. - PubMed
4. 1. Ashton G.H., Sorelli,P., Mellerio,J.E., Keane,F.M., Eady,R.A. and McGrath,J.A. (2001) α6β4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia. Br. J. Dermatol., 144, 408–414. - PubMed
5. 1. Bagutti C., Speight,P.M. and Watt,F.M. (1998) Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity. J. Pathol., 186, 8–16. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Nature Publishing Group
  • Ovid Technologies, Inc.
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database