The two faces of BRCA2, a FANCtastic discovery - PubMed (original) (raw)
The two faces of BRCA2, a FANCtastic discovery
Grant Stewart et al. Mol Cell. 2002 Jul.
Free article
Abstract
The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.
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