Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein - PubMed (original) (raw)
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
Sung Hee Baek et al. Cell. 2002.
Free article
Abstract
Defining the molecular mechanisms that integrate diverse signaling pathways at the level of gene transcription remains a central issue in biology. Here, we demonstrate that interleukin-1beta (IL-1beta) causes nuclear export of a specific N-CoR corepressor complex, resulting in derepression of a specific subset of NF-kappaB-regulated genes, exemplified by the tetraspanin KAI1 that regulates membrane receptor function. Nuclear export of the N-CoR/TAB2/HDAC3 complex by IL-1beta is temporally linked to selective recruitment of a Tip60 coactivator complex. Surprisingly, KAI1 is also directly activated by a ternary complex, dependent on the acetyltransferase activity of Tip60, consisting of the presenilin-dependent C-terminal cleavage product of the amyloid beta precursor protein (APP), Fe65, and Tip60, identifying a specific in vivo gene target of an APP-dependent transcription complex in the brain.
Similar articles
- The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.
von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U. von Rotz RC, et al. J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48. doi: 10.1242/jcs.01323. J Cell Sci. 2004. PMID: 15331662 - Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld MG, Baek SH. Kim JH, et al. Nature. 2005 Apr 14;434(7035):921-6. doi: 10.1038/nature03452. Nature. 2005. PMID: 15829968 - A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
Hass MR, Yankner BA. Hass MR, et al. J Biol Chem. 2005 Nov 4;280(44):36895-904. doi: 10.1074/jbc.M502861200. Epub 2005 Aug 15. J Biol Chem. 2005. PMID: 16103124 Free PMC article. - Cellular functions of TIP60.
Sapountzi V, Logan IR, Robson CN. Sapountzi V, et al. Int J Biochem Cell Biol. 2006;38(9):1496-509. doi: 10.1016/j.biocel.2006.03.003. Epub 2006 Mar 28. Int J Biochem Cell Biol. 2006. PMID: 16698308 Review. - A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.
Słomnicki LP, Leśniak W. Słomnicki LP, et al. Acta Neurobiol Exp (Wars). 2008;68(2):219-28. doi: 10.55782/ane-2008-1691. Acta Neurobiol Exp (Wars). 2008. PMID: 18511958 Review.
Cited by
- Integrative Multi-omics Analysis to Characterize Herpes Virus Infection Increases the Risk of Alzheimer's Disease.
Wang Y, Tang Y, Liu TH, Shao L, Li C, Wang Y, Tan P. Wang Y, et al. Mol Neurobiol. 2024 Aug;61(8):5337-5352. doi: 10.1007/s12035-023-03903-w. Epub 2024 Jan 8. Mol Neurobiol. 2024. PMID: 38191694 - Circular RNA in Non-small Cell Lung Carcinoma: Identification of Targets and New Treatment Modalities.
Weidle UH, Birzele F. Weidle UH, et al. Cancer Genomics Proteomics. 2023 Dec;20(6suppl):646-668. doi: 10.21873/cgp.20413. Cancer Genomics Proteomics. 2023. PMID: 38035705 Free PMC article. Review. - RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.
Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. Abe Y, et al. Mol Cell. 2023 Oct 5;83(19):3421-3437.e11. doi: 10.1016/j.molcel.2023.08.029. Epub 2023 Sep 25. Mol Cell. 2023. PMID: 37751740 Free PMC article. - An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology.
Foutadakis S, Roupakia E, Liakopoulos P, Kolovos P, Kolettas E. Foutadakis S, et al. Cancers (Basel). 2022 Oct 14;14(20):5047. doi: 10.3390/cancers14205047. Cancers (Basel). 2022. PMID: 36291831 Free PMC article. - Alzheimer's disease: Pathophysiology and dental pulp stem cells therapeutic prospects.
Xiong W, Liu Y, Zhou H, Jing S, He Y, Ye Q. Xiong W, et al. Front Cell Dev Biol. 2022 Sep 15;10:999024. doi: 10.3389/fcell.2022.999024. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36187488 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous