Unsafe SETs: histone lysine methyltransferases and cancer - PubMed (original) (raw)
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Unsafe SETs: histone lysine methyltransferases and cancer
Robert Schneider et al. Trends Biochem Sci. 2002 Aug.
Abstract
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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