Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth - PubMed (original) (raw)
. 2002 Jul 18;35(2):283-90.
doi: 10.1016/s0896-6273(02)00770-5.
Zixuan Cao, Timothy Spencer, Rajeev Sivasankaran, Kevin Wang, Elena Nikulina, Noriko Kimura, Hong Cai, Kangwen Deng, Ying Gao, Zhigang He, Marie Filbin
Affiliations
- PMID: 12160746
- DOI: 10.1016/s0896-6273(02)00770-5
Free article
Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth
Marco Domeniconi et al. Neuron. 2002.
Free article
Abstract
Myelin inhibitors of axonal regeneration, like Nogo and MAG, block regrowth after injury to the adult CNS. While a GPI-linked receptor for Nogo (NgR) has been identified, MAG's receptor is unknown. We show that MAG inhibits regeneration by interaction with NgR. Binding of and inhibition by MAG are lost if neuronal GPI-linked proteins are cleaved. Binding of MAG to NgR-expressing cells is GPI dependent and sialic acid independent. Conversely, NgR binds to MAG-expressing cells. MAG, but not a truncated MAG that binds neurons but does not inhibit regeneration, precipitates NgR from NgR-expressing cells, DRG, and cerebellar neurons. Importantly, NgR antibody, soluble NgR, or dominant-negative NgR each prevent inhibition of neurite outgrowth by MAG. Also, MAG and Nogo66 compete for binding to NgR. These results suggest redundancy in myelin inhibitors and indicate therapies for CNS injuries.
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