Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain - PubMed (original) (raw)

Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

Takeshi Uemura et al. Biochem Biophys Res Commun. 2002.

Abstract

We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRalpha1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking.

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