Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration - PubMed (original) (raw)
Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
Makoto Higuchi et al. Neuron. 2002.
Free article
Abstract
Frontotemporal dementias (FTDs), including corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), are neurodegenerative tauopathies characterized by widespread CNS neuronal and glial tau pathologies, but there are no tau transgenic (Tg) mice that model neurodegeneration with glia tau lesions. Thus, we generated Tg mice overexpressing human tau in neurons and glia. No neuronal tau aggregates were detected, but old mice developed Thioflavin S- and Gallyas-positive glial tau pathology resembling CBD astrocytic plaques. Tau-immunoreactive and Gallyas-positive oligodendroglial coiled bodies (similar to CBD and PSP), glial degeneration, and motor deficits were associated with age-dependent accumulations of insoluble hyperphosphorylated human tau and tau immunopositive filaments in degenerating glial cells. Thus, tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration.
Similar articles
- Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity.
Fu YJ, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koike R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H. Fu YJ, et al. Acta Neuropathol. 2010 Jul;120(1):21-32. doi: 10.1007/s00401-010-0649-2. Epub 2010 Feb 7. Acta Neuropathol. 2010. PMID: 20140439 - Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies.
Yoshida M. Yoshida M. Neuropathology. 2006 Oct;26(5):457-70. doi: 10.1111/j.1440-1789.2006.00743.x. Neuropathology. 2006. PMID: 17080726 - Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration.
Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM, Trojanowski JQ. Forman MS, et al. J Neurosci. 2005 Apr 6;25(14):3539-50. doi: 10.1523/JNEUROSCI.0081-05.2005. J Neurosci. 2005. PMID: 15814784 Free PMC article. - [Neuropathology of tauopathy].
Yoshida M. Yoshida M. Brain Nerve. 2013 Dec;65(12):1445-58. Brain Nerve. 2013. PMID: 24323931 Review. Japanese. - Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasome inhibition.
Richter-Landsberg C, Bauer NG. Richter-Landsberg C, et al. Int J Dev Neurosci. 2004 Nov;22(7):443-51. doi: 10.1016/j.ijdevneu.2004.07.003. Int J Dev Neurosci. 2004. PMID: 15465274 Review.
Cited by
- Toward an animal model of Progressive Supranuclear Palsy.
Priyanka, Qamar SH, Visanji NP. Priyanka, et al. Front Neurosci. 2024 Oct 3;18:1433465. doi: 10.3389/fnins.2024.1433465. eCollection 2024. Front Neurosci. 2024. PMID: 39420986 Free PMC article. Review. - Vaccination as a therapeutic approach to Alzheimer's disease.
Wisniewski T, Boutajangout A. Wisniewski T, et al. Mt Sinai J Med. 2010 Jan-Feb;77(1):17-31. doi: 10.1002/msj.20156. Mt Sinai J Med. 2010. PMID: 20101719 Free PMC article. Review. - A decade of tau transgenic animal models and beyond.
Götz J, Deters N, Doldissen A, Bokhari L, Ke Y, Wiesner A, Schonrock N, Ittner LM. Götz J, et al. Brain Pathol. 2007 Jan;17(1):91-103. doi: 10.1111/j.1750-3639.2007.00051.x. Brain Pathol. 2007. PMID: 17493043 Free PMC article. Review. - Tau protein expression in adult bovine oligodendrocytes: functional and pathological significance.
Ksiezak-Reding H, Farooq M, Yang LS, Dickson DW, LoPresti P. Ksiezak-Reding H, et al. Neurochem Res. 2003 Sep;28(9):1385-92. doi: 10.1023/a:1024952600774. Neurochem Res. 2003. PMID: 12938862 - Protein astrogliopathies in human neurodegenerative diseases and aging.
Kovacs GG, Lee VM, Trojanowski JQ. Kovacs GG, et al. Brain Pathol. 2017 Sep;27(5):675-690. doi: 10.1111/bpa.12536. Brain Pathol. 2017. PMID: 28805003 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous