Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy - PubMed (original) (raw)
Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy
Roberto De Marco et al. J Allergy Clin Immunol. 2002 Aug.
Abstract
Background: The knowledge of the natural history of asthma from birth to adulthood could provide important clues for its cause and for the understanding of epidemiologic findings.
Objective: This study is aimed at assessing the incidence and remission of asthma from birth to the age of 44 years by using data from 18,873 subjects involved in a large, nationally representative, cross-sectional study carried out in Italy from 1998 through 2000.
Methods: The onset of asthma was defined as the age at the first attack, and remission was considered present when a subject was neither under treatment nor had experienced an asthma attack in the last 24 months. Person-years and survival techniques were used for the analysis.
Results: The average annual incidence rate for the 1953 to 2000 period was 2.56/1000 persons per year. Incidence peaked in boys less than 10 years of age (4.38/1000 persons per year) and in women 30 years of age or older (3.1/1000 persons per year) and showed a generational increase (incident rate ratio = 2.63 and 95% CI = 2.20-3.12 for 1974-1979 vs 1953-1958 birth cohort). The overall remission rate was 45.8% (41.6% in women and 49.5% in men, P <.001). Asthmatic patients in remission had an earlier age at onset (7.8 vs 15.9 years, P <.001) and a shorter duration of the disease (5.6 vs 16.1 years, P <.001) than patients with current asthma. The probability of remission was strongly (P <.001) and inversely related to the age at onset (62.8% and 15.0% in the <10- and > or =20-years age-at-onset groups, respectively).
Conclusion: With respect to its natural history, asthma presents 2 different forms: early-onset asthma, which occurs early in childhood, affects mainly boys, and has a good prognosis, and late-onset asthma, which generally occurs during or after puberty, mainly affects women, and has a poor prognosis. The minority of patients with early-onset asthma who do not remit represents more than 35% of patients with current asthma in the general young adult population.
Similar articles
- Influence of early life exposures on incidence and remission of asthma throughout life.
de Marco R, Pattaro C, Locatelli F, Svanes C; ECRHS Study Group. de Marco R, et al. J Allergy Clin Immunol. 2004 May;113(5):845-52. doi: 10.1016/j.jaci.2004.01.780. J Allergy Clin Immunol. 2004. PMID: 15131565 - The course of asthma: A population-based 10-year study examining asthma remission in children diagnosed with asthma in preschool.
Oluwole O, Rennie DC, Goodridge D, Blackburn D, Litzenberger T, Penz E, Lawson JA. Oluwole O, et al. Pediatr Pulmonol. 2020 Aug;55(8):1924-1935. doi: 10.1002/ppul.24881. Epub 2020 Jun 9. Pediatr Pulmonol. 2020. PMID: 32478962 - Italian cancer figures, report 2012: Cancer in children and adolescents.
AIRTUM Working Group; CCM; AIEOP Working Group. AIRTUM Working Group, et al. Epidemiol Prev. 2013 Jan-Feb;37(1 Suppl 1):1-225. Epidemiol Prev. 2013. PMID: 23585445 English, Italian. - Early-life determinants of asthma from birth to age 20 years: a German birth cohort study.
Grabenhenrich LB, Gough H, Reich A, Eckers N, Zepp F, Nitsche O, Forster J, Schuster A, Schramm D, Bauer CP, Hoffmann U, Beschorner J, Wagner P, Bergmann R, Bergmann K, Matricardi PM, Wahn U, Lau S, Keil T. Grabenhenrich LB, et al. J Allergy Clin Immunol. 2014 Apr;133(4):979-88. doi: 10.1016/j.jaci.2013.11.035. Epub 2014 Jan 22. J Allergy Clin Immunol. 2014. PMID: 24461583 - The epidemiology and natural history of asthma.
Bonner JR. Bonner JR. Clin Chest Med. 1984 Dec;5(4):557-65. Clin Chest Med. 1984. PMID: 6394196 Review.
Cited by
- Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation.
Bracken SJ, Adami AJ, Szczepanek SM, Ehsan M, Natarajan P, Guernsey LA, Shahriari N, Rafti E, Matson AP, Schramm CM, Thrall RS. Bracken SJ, et al. Int Arch Allergy Immunol. 2015;166(4):243-58. doi: 10.1159/000381058. Epub 2015 Apr 28. Int Arch Allergy Immunol. 2015. PMID: 25924733 Free PMC article. - Adverse respiratory outcomes among patients with resolved asthma: matched retrospective cohort study.
Jones H, Cumins B, Cannings-John R, Ahmed H. Jones H, et al. Br J Gen Pract. 2024 May 30;74(743):e364-e370. doi: 10.3399/BJGP.2023.0271. Print 2024 Jun. Br J Gen Pract. 2024. PMID: 38242713 Free PMC article. - Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies.
Zhang GQ, Özuygur Ermis SS, Rådinger M, Bossios A, Kankaanranta H, Nwaru B. Zhang GQ, et al. J Asthma Allergy. 2022 Feb 18;15:231-247. doi: 10.2147/JAA.S282667. eCollection 2022. J Asthma Allergy. 2022. PMID: 35210789 Free PMC article. Review. - [A Study of the Prevalence of Asthma in the General Population in Spain].
Blanco-Aparicio M, García-Río FJ, González-Barcala FJ, Jiménez-Ruiz CA, Muñoz X, Plaza V, Soto-Campos JG, Urrutia-Landa I, Almonacid C, Peces-Barba G, Álvarez-Gutiérrez FJ. Blanco-Aparicio M, et al. Open Respir Arch. 2023 Apr 17;5(2):100245. doi: 10.1016/j.opresp.2023.100245. eCollection 2023 Apr-Jun. Open Respir Arch. 2023. PMID: 37496876 Free PMC article. Spanish. - Late-Onset Asthma: A Diagnostic and Management Challenge.
Ulrik CS. Ulrik CS. Drugs Aging. 2017 Mar;34(3):157-162. doi: 10.1007/s40266-017-0437-y. Drugs Aging. 2017. PMID: 28164255
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical