Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival - PubMed (original) (raw)

Affiliations

PMID: 12171889

Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival

Tohru Utsunomiya et al. Clin Cancer Res. 2002 Aug.

Abstract

Purpose and experimental design: We previously reported that an increased expression of cystatin-like metastasis-associated protein (CMAP) mRNA is involved in liver-specific metastasis in a mouse model. We also identified its human homologue and showed that the expression of CMAP in various human cancer cell lines correlated with the description of malignancy in these cell lines. However, there is still no information available on the clinical significance of CMAP expression in human cancer specimens. Thus, we studied the CMAP expression levels using a real-time quantitative reverse transcription-PCR for 79 patients with colorectal cancer, including 17 cases with liver metastasis.

Results: The mean expression level of CMAP in tumor tissue specimens was significantly higher than in the corresponding normal tissue specimens (P < 0.05). A higher expression of CMAP was significantly correlated with liver metastasis (P < 0.01) as well as with a less differentiated histological type (P < 0.05) of colorectal cancer. An increased expression of CMAP was also identified as the strongest independent factor for liver metastasis based on a multivariate analysis (P < 0.001). Furthermore, the prognosis of the patients with a higher expression of CMAP was significantly worse than those with a lower expression (5-year survival rate; 49.7% and 75.0%, respectively, P = 0.038).

Conclusions: These findings imply that the expression level of CMAP in human cancer may be a new biomarker for both liver metastasis and the patient's outcome.

PubMed Disclaimer

Cited by

Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden.
Kwon WS, Kim TS, Nahm CH, Moon Y, Kim JJ. Kwon WS, et al. Oncol Lett. 2018 Nov;16(5):5583-5590. doi: 10.3892/ol.2018.9380. Epub 2018 Sep 3. Oncol Lett. 2018. PMID: 30344712 Free PMC article.
An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription.
Su Z, Liu Y, Xia Z, Rustgi AK, Gu W. Su Z, et al. Sci Adv. 2024 Jun 7;10(23):eadm9481. doi: 10.1126/sciadv.adm9481. Epub 2024 Jun 5. Sci Adv. 2024. PMID: 38838145 Free PMC article.
Cystatin F acts as a mediator of immune suppression in glioblastoma.
Senjor E, Perišić Nanut M, Breznik B, Mitrović A, Mlakar J, Rotter A, Porčnik A, Lah Turnšek T, Kos J. Senjor E, et al. Cell Oncol (Dordr). 2021 Oct;44(5):1051-1063. doi: 10.1007/s13402-021-00618-9. Epub 2021 Jun 29. Cell Oncol (Dordr). 2021. PMID: 34189679
Cystatin F as a regulator of immune cell cytotoxicity.
Kos J, Nanut MP, Prunk M, Sabotič J, Dautović E, Jewett A. Kos J, et al. Cancer Immunol Immunother. 2018 Dec;67(12):1931-1938. doi: 10.1007/s00262-018-2165-5. Epub 2018 May 10. Cancer Immunol Immunother. 2018. PMID: 29748898 Free PMC article. Review.
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma.
Sudo T, Utsunomiya T, Mimori K, Nagahara H, Ogawa K, Inoue H, Wakiyama S, Fujita H, Shirouzu K, Mori M. Sudo T, et al. Br J Cancer. 2005 May 9;92(9):1754-8. doi: 10.1038/sj.bjc.6602531. Br J Cancer. 2005. PMID: 15856046 Free PMC article.

Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival - PubMed (original) (raw)