LINE drive. retrotransposition and genome instability - PubMed (original) (raw)
Review
. 2002 Aug 9;110(3):277-80.
doi: 10.1016/s0092-8674(02)00868-1.
Affiliations
- PMID: 12176313
- DOI: 10.1016/s0092-8674(02)00868-1
Free article
Review
LINE drive. retrotransposition and genome instability
Haig H Kazazian Jr et al. Cell. 2002.
Free article
Abstract
The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.
Comment on
- Genomic deletions created upon LINE-1 retrotransposition.
Gilbert N, Lutz-Prigge S, Moran JV. Gilbert N, et al. Cell. 2002 Aug 9;110(3):315-25. doi: 10.1016/s0092-8674(02)00828-0. Cell. 2002. PMID: 12176319 - Human l1 retrotransposition is associated with genetic instability in vivo.
Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, Parmigiani G, Boeke JD. Symer DE, et al. Cell. 2002 Aug 9;110(3):327-38. doi: 10.1016/s0092-8674(02)00839-5. Cell. 2002. PMID: 12176320