Dynamic remodeling of transcription complexes by molecular chaperones - PubMed (original) (raw)
Review
. 2002 Aug 9;110(3):281-4.
doi: 10.1016/s0092-8674(02)00860-7.
Affiliations
- PMID: 12176314
- DOI: 10.1016/s0092-8674(02)00860-7
Free article
Review
Dynamic remodeling of transcription complexes by molecular chaperones
Richard I Morimoto. Cell. 2002.
Free article
Abstract
The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.
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