Dynamic remodeling of transcription complexes by molecular chaperones - PubMed (original) (raw)

Review

. 2002 Aug 9;110(3):281-4.

doi: 10.1016/s0092-8674(02)00860-7.

Affiliations

Free article

Review

Dynamic remodeling of transcription complexes by molecular chaperones

Richard I Morimoto. Cell. 2002.

Free article

Abstract

The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources