Toc, tic, and chloroplast protein import - PubMed (original) (raw)
Review
. 2002 Jun 12;1590(1-3):177-89.
doi: 10.1016/s0167-4889(02)00176-3.
Affiliations
- PMID: 12180471
- DOI: 10.1016/s0167-4889(02)00176-3
Free article
Review
Toc, tic, and chloroplast protein import
Paul Jarvis et al. Biochim Biophys Acta. 2002.
Free article
Abstract
The vast majority of chloroplast proteins are synthesized in precursor form on cytosolic ribosomes. Chloroplast precursor proteins have cleavable, N-terminal targeting signals called transit peptides. Transit peptides direct precursor proteins to the chloroplast in an organelle-specific way. They can be phosphorylated by a cytosolic protein kinase, and this leads to the formation of a cytosolic guidance complex. The guidance complex--comprising precursor, hsp70 and 14-3-3 proteins, as well as several unidentified components--docks at the outer envelope membrane. Translocation of precursor proteins across the envelope is achieved by the joint action of molecular machines called Toc (translocon at the outer envelope membrane of chloroplasts) and Tic (translocon at the inner envelope membrane of chloroplasts), respectively. The action of the Toc/Tic apparatus requires the hydrolysis of ATP and GTP at different levels, indicating energetic requirements and regulatory properties of the import process. The main subunits of the Toc and Tic complexes have been identified and characterized in vivo, in organello and in vitro. Phylogenetic evidence suggests that several translocon subunits are of cyanobacterial origin, indicating that today's import machinery was built around a prokaryotic core.
Corrected and republished from
- Toc, Tic, and chloroplast protein import.
Jarvis P, Soll J. Jarvis P, et al. Biochim Biophys Acta. 2001 Dec 12;1541(1-2):64-79. doi: 10.1016/s0167-4889(01)00147-1. Biochim Biophys Acta. 2001. PMID: 11750663 Corrected and republished. Review.
Similar articles
- Toc, Tic, and chloroplast protein import.
Jarvis P, Soll J. Jarvis P, et al. Biochim Biophys Acta. 2001 Dec 12;1541(1-2):64-79. doi: 10.1016/s0167-4889(01)00147-1. Biochim Biophys Acta. 2001. PMID: 11750663 Corrected and republished. Review. - Molecular Topology of the Transit Peptide during Chloroplast Protein Import.
Richardson LGL, Small EL, Inoue H, Schnell DJ. Richardson LGL, et al. Plant Cell. 2018 Aug;30(8):1789-1806. doi: 10.1105/tpc.18.00172. Epub 2018 Jul 10. Plant Cell. 2018. PMID: 29991536 Free PMC article. - Stable megadalton TOC-TIC supercomplexes as major mediators of protein import into chloroplasts.
Chen LJ, Li HM. Chen LJ, et al. Plant J. 2017 Oct;92(2):178-188. doi: 10.1111/tpj.13643. Epub 2017 Sep 15. Plant J. 2017. PMID: 28745032 - Protein transport in organelles: The Toc complex way of preprotein import.
Agne B, Kessler F. Agne B, et al. FEBS J. 2009 Mar;276(5):1156-65. doi: 10.1111/j.1742-4658.2009.06873.x. FEBS J. 2009. PMID: 19187236 Review. - TIC236 links the outer and inner membrane translocons of the chloroplast.
Chen YL, Chen LJ, Chu CC, Huang PK, Wen JR, Li HM. Chen YL, et al. Nature. 2018 Dec;564(7734):125-129. doi: 10.1038/s41586-018-0713-y. Epub 2018 Nov 21. Nature. 2018. PMID: 30464337
Cited by
- The caseinolytic protease complex component CLPC1 in Arabidopsis maintains proteome and RNA homeostasis in chloroplasts.
Zhang S, Zhang H, Xia Y, Xiong L. Zhang S, et al. BMC Plant Biol. 2018 Sep 12;18(1):192. doi: 10.1186/s12870-018-1396-0. BMC Plant Biol. 2018. PMID: 30208840 Free PMC article. - Primary endosymbiosis and the evolution of light and oxygen sensing in photosynthetic eukaryotes.
Rockwell NC, Lagarias JC, Bhattacharya D. Rockwell NC, et al. Front Ecol Evol. 2014;2(66):10.3389/fevo.2014.00066. doi: 10.3389/fevo.2014.00066. Front Ecol Evol. 2014. PMID: 25729749 Free PMC article. - The Induction of Recombinant Protein Bodies in Different Subcellular Compartments Reveals a Cryptic Plastid-Targeting Signal in the 27-kDa γ-Zein Sequence.
Hofbauer A, Peters J, Arcalis E, Rademacher T, Lampel J, Eudes F, Vitale A, Stoger E. Hofbauer A, et al. Front Bioeng Biotechnol. 2014 Dec 11;2:67. doi: 10.3389/fbioe.2014.00067. eCollection 2014. Front Bioeng Biotechnol. 2014. PMID: 25566533 Free PMC article. - The mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles.
Hovde BT, Starkenburg SR, Hunsperger HM, Mercer LD, Deodato CR, Jha RK, Chertkov O, Monnat RJ Jr, Cattolico RA. Hovde BT, et al. BMC Genomics. 2014 Jul 17;15:604. doi: 10.1186/1471-2164-15-604. BMC Genomics. 2014. PMID: 25034814 Free PMC article. - Comparative proteomics of chloroplasts envelopes from bundle sheath and mesophyll chloroplasts reveals novel membrane proteins with a possible role in c4-related metabolite fluxes and development.
Manandhar-Shrestha K, Tamot B, Pratt EP, Saitie S, Bräutigam A, Weber AP, Hoffmann-Benning S. Manandhar-Shrestha K, et al. Front Plant Sci. 2013 Mar 28;4:65. doi: 10.3389/fpls.2013.00065. eCollection 2013. Front Plant Sci. 2013. PMID: 23543921 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources