Mechanisms of Pavlovian fear conditioning: has the engram been located? - PubMed (original) (raw)
Review
. 2002 Sep;25(9):436-7; discussion 437-8.
doi: 10.1016/s0166-2236(02)02243-9.
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- PMID: 12183195
- DOI: 10.1016/s0166-2236(02)02243-9
Review
Mechanisms of Pavlovian fear conditioning: has the engram been located?
Denis Paré. Trends Neurosci. 2002 Sep.
Abstract
Uncertainty persists as to whether the amygdala is a crucial site of plasticity for classically conditioned fear or merely a sensory relay to structures generating fear responses. A recent Nature study suggests that associative synaptic changes take place in neurons of the amygdala during fear conditioning, and that these changes require dopamine-mediated modulation. Nevertheless, these findings do not prove that the amygdala is a sufficient site of plasticity for fear memory.
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