Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis? - PubMed (original) (raw)
. 2002 Sep;125(Pt 9):1972-9.
doi: 10.1093/brain/awf216.
Affiliations
- PMID: 12183343
- DOI: 10.1093/brain/awf216
Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis?
Perrine Charles et al. Brain. 2002 Sep.
Abstract
Multiple sclerosis is affecting approximately 1 out of every 1000 individuals in the western world. After axons are denuded of myelin in the early stages of the disease, remyelination occurs, but eventually this process fails, and permanent disability is the result. During development, the polysialylated form of the neural cell adhesion molecule NCAM, PSA-NCAM, is expressed at the axonal surface and acts as a negative regulator of myelination, presumably by preventing myelin-forming cells from attaching to the axon. Removal of PSA-NCAM from the axonal surface is a prerequisite for the initiation of myelination. We questioned whether, in multiple sclerosis, re-expression of PSA-NCAM by axons could occur, and therefore account for the failure of remyelination. Forty multiple sclerosis lesions from 24 different post-mortem multiple sclerosis cases were selected by histological methods and analysed by immunohistochemistry. Demyelinated lesions and partially remyelinated lesions (shadow plaques) were studied. Controls consisted of post-mortem brain tissue from patients with amyotrophic lateral sclerosis and without neurological disease. We showed that PSA-NCAM, normally absent from adult brain, is re-expressed on demyelinated axons in the plaques. Within shadow plaques, remyelinated axons do not express PSA-NCAM. Re-expression of PSA-NCAM could act as an inhibitor of remyelination and participate in disease progression in multiple sclerosis.
Similar articles
- Expression of the highly polysialylated neural cell adhesion molecule during postnatal myelination and following chemically induced demyelination of the adult mouse spinal cord.
Nait Oumesmar B, Vignais L, Duhamel-Clérin E, Avellana-Adalid V, Rougon G, Baron-Van Evercooren A. Nait Oumesmar B, et al. Eur J Neurosci. 1995 Mar 1;7(3):480-91. doi: 10.1111/j.1460-9568.1995.tb00344.x. Eur J Neurosci. 1995. PMID: 7773445 - The polysialylated neural cell adhesion molecule reaches cell surfaces of hypothalamic neurons and astrocytes via the constitutive pathway.
Pierre K, Bonhomme R, Dupouy B, Poulain DA, Theodosis DT. Pierre K, et al. Neuroscience. 2001;103(1):133-42. doi: 10.1016/s0306-4522(00)00536-4. Neuroscience. 2001. PMID: 11311794 - Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain.
Jakovcevski I, Mo Z, Zecevic N. Jakovcevski I, et al. Neuroscience. 2007 Oct 26;149(2):328-37. doi: 10.1016/j.neuroscience.2007.07.044. Epub 2007 Aug 8. Neuroscience. 2007. PMID: 17900814 Free PMC article. - Endogeneous remyelination: findings in human studies.
Kipp M, Victor M, Martino G, Franklin RJ. Kipp M, et al. CNS Neurol Disord Drug Targets. 2012 Aug;11(5):598-609. doi: 10.2174/187152712801661257. CNS Neurol Disord Drug Targets. 2012. PMID: 22583436 Review. - [The impact of polysialic acid (PSA) and polysialylated neural cell adhesion molecule (PSA-NCAM) on tumor and cell signaling pathways].
Wang X, Guan F. Wang X, et al. Yi Chuan. 2014 Aug;36(8):739-46. doi: 10.3724/SP.J.1005.2014.0739. Yi Chuan. 2014. PMID: 25143271 Review. Chinese.
Cited by
- Biological function of sialic acid and sialylation in human health and disease.
Zhu W, Zhou Y, Guo L, Feng S. Zhu W, et al. Cell Death Discov. 2024 Sep 30;10(1):415. doi: 10.1038/s41420-024-02180-3. Cell Death Discov. 2024. PMID: 39349440 Free PMC article. Review. - Predicting multiple sclerosis severity with multimodal deep neural networks.
Zhang K, Lincoln JA, Jiang X, Bernstam EV, Shams S. Zhang K, et al. BMC Med Inform Decis Mak. 2023 Nov 9;23(1):255. doi: 10.1186/s12911-023-02354-6. BMC Med Inform Decis Mak. 2023. PMID: 37946182 Free PMC article. - ALCAM on human oligodendrocytes mediates CD4 T cell adhesion.
Jamann H, Desu HL, Cui QL, Halaweh A, Tastet O, Klement W, Zandee S, Pernin F, Mamane VH, Ouédraogo O, Daigneault A, Sidibé H, Millette F, Peelen E, Dhaeze T, Hoornaert C, Rébillard RM, Thai K, Grasmuck C, Vande Velde C, Prat A, Arbour N, Stratton JA, Antel J, Larochelle C. Jamann H, et al. Brain. 2024 Jan 4;147(1):147-162. doi: 10.1093/brain/awad286. Brain. 2024. PMID: 37640028 Free PMC article. - Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization.
Schröder LJ, Thiesler H, Gretenkort L, Möllenkamp TM, Stangel M, Gudi V, Hildebrandt H. Schröder LJ, et al. Front Cell Neurosci. 2023 Jul 10;17:1207540. doi: 10.3389/fncel.2023.1207540. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37492129 Free PMC article. - Inflammation in multiple sclerosis: consequences for remyelination and disease progression.
Klotz L, Antel J, Kuhlmann T. Klotz L, et al. Nat Rev Neurol. 2023 May;19(5):305-320. doi: 10.1038/s41582-023-00801-6. Epub 2023 Apr 14. Nat Rev Neurol. 2023. PMID: 37059811 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous