Mitochondrial processing peptidases - PubMed (original) (raw)

Review

. 2002 Sep 2;1592(1):63-77.

doi: 10.1016/s0167-4889(02)00265-3.

Affiliations

• PMID: 12191769
• DOI: 10.1016/s0167-4889(02)00265-3

Free article

Review

Mitochondrial processing peptidases

Oleksandr Gakh et al. Biochim Biophys Acta. 2002.

Free article

Abstract

Three peptidases are responsible for the proteolytic processing of both nuclearly and mitochondrially encoded precursor polypeptides targeted to the various subcompartments of the mitochondria. Mitochondrial processing peptidase (MPP) cleaves the vast majority of mitochondrial proteins, while inner membrane peptidase (IMP) and mitochondrial intermediate peptidase (MIP) process specific subsets of precursor polypeptides. All three enzymes are structurally and functionally conserved across species, and their human homologues begin to be recognized as potential players in mitochondrial disease.

PubMed Disclaimer

Similar articles

• The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase.
  Murcha MW, Elhafez D, Millar AH, Whelan J. Murcha MW, et al. J Mol Biol. 2004 Nov 19;344(2):443-54. doi: 10.1016/j.jmb.2004.09.045. J Mol Biol. 2004. PMID: 15522297
• Mitochondrial processing peptidase: multiple-site recognition of precursor proteins.
  Ito A. Ito A. Biochem Biophys Res Commun. 1999 Nov 30;265(3):611-6. doi: 10.1006/bbrc.1999.1703. Biochem Biophys Res Commun. 1999. PMID: 10600469 Review.
• Prediction and identification of new natural substrates of the yeast mitochondrial intermediate peptidase.
  Branda SS, Isaya G. Branda SS, et al. J Biol Chem. 1995 Nov 10;270(45):27366-73. doi: 10.1074/jbc.270.45.27366. J Biol Chem. 1995. PMID: 7593000
• More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites.
  Friedl J, Knopp MR, Groh C, Paz E, Gould SB, Herrmann JM, Boos F. Friedl J, et al. Mol Biol Cell. 2020 Nov 15;31(24):2657-2668. doi: 10.1091/mbc.E20-08-0524. Epub 2020 Sep 30. Mol Biol Cell. 2020. PMID: 32997570 Free PMC article.
• Mitochondrial Processing Peptidases-Structure, Function and the Role in Human Diseases.
  Kunová N, Havalová H, Ondrovičová G, Stojkovičová B, Bauer JA, Bauerová-Hlinková V, Pevala V, Kutejová E. Kunová N, et al. Int J Mol Sci. 2022 Jan 24;23(3):1297. doi: 10.3390/ijms23031297. Int J Mol Sci. 2022. PMID: 35163221 Free PMC article. Review.

Cited by

• Pathophysiology of Arginases in Cancer and Efforts in Their Pharmacological Inhibition.
  Marzęta-Assas P, Jacenik D, Zasłona Z. Marzęta-Assas P, et al. Int J Mol Sci. 2024 Sep 10;25(18):9782. doi: 10.3390/ijms25189782. Int J Mol Sci. 2024. PMID: 39337272 Free PMC article. Review.
• The cytosolic form of dual localized BolA family protein Bol3 is important for adaptation to iron starvation in Aspergillus fumigatus.
  Oberegger S, Misslinger M, Faserl K, Sarg B, Farhan H, Haas H. Oberegger S, et al. Open Biol. 2024 Jun;14(6):240033. doi: 10.1098/rsob.240033. Epub 2024 Jun 26. Open Biol. 2024. PMID: 38919062 Free PMC article.
• Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR).
  Goldstein SI, Fan AC, Wang Z, Naineni SK, Lengqvist J, Chernobrovkin A, Garcia-Gutierrez SB, Cencic R, Patel K, Huang S, Brown LE, Emili A, Porco JA Jr. Goldstein SI, et al. bioRxiv [Preprint]. 2024 Apr 19:2024.04.19.590252. doi: 10.1101/2024.04.19.590252. bioRxiv. 2024. PMID: 38659867 Free PMC article. Preprint.
• Expression and processing of mature human frataxin after gene therapy in mice.
  Rojsajjakul T, Selvan N, De B, Rosenberg JB, Kaminsky SM, Sondhi D, Janki P, Crystal RG, Mesaros C, Khanna R, Blair IA. Rojsajjakul T, et al. Sci Rep. 2024 Apr 10;14(1):8391. doi: 10.1038/s41598-024-59060-0. Sci Rep. 2024. PMID: 38600238 Free PMC article.
• Widespread stable noncanonical peptides identified by integrated analyses of ribosome profiling and ORF features.
  Yang H, Li Q, Stroup EK, Wang S, Ji Z. Yang H, et al. Nat Commun. 2024 Mar 2;15(1):1932. doi: 10.1038/s41467-024-46240-9. Nat Commun. 2024. PMID: 38431639 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase
  • Saccharomyces Genome Database