Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting - PubMed (original) (raw)
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting
Markus Babst et al. Dev Cell. 2002 Aug.
Free article
Abstract
The sorting of transmembrane proteins (e.g., cell surface receptors) into the multivesicular body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT protein complexes. The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20. The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes.
Similar articles
- Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Babst M, Katzmann DJ, Snyder WB, Wendland B, Emr SD. Babst M, et al. Dev Cell. 2002 Aug;3(2):283-9. doi: 10.1016/s1534-5807(02)00219-8. Dev Cell. 2002. PMID: 12194858 - Vps27 recruits ESCRT machinery to endosomes during MVB sorting.
Katzmann DJ, Stefan CJ, Babst M, Emr SD. Katzmann DJ, et al. J Cell Biol. 2003 Aug 4;162(3):413-23. doi: 10.1083/jcb.200302136. J Cell Biol. 2003. PMID: 12900393 Free PMC article. - Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation.
Teis D, Saksena S, Emr SD. Teis D, et al. Dev Cell. 2008 Oct;15(4):578-89. doi: 10.1016/j.devcel.2008.08.013. Dev Cell. 2008. PMID: 18854142 - Protein sorting into multivesicular endosomes.
Raiborg C, Rusten TE, Stenmark H. Raiborg C, et al. Curr Opin Cell Biol. 2003 Aug;15(4):446-55. doi: 10.1016/s0955-0674(03)00080-2. Curr Opin Cell Biol. 2003. PMID: 12892785 Review. - Phosphoinositides in the mammalian endo-lysosomal network.
Cullen PJ, Carlton JG. Cullen PJ, et al. Subcell Biochem. 2012;59:65-110. doi: 10.1007/978-94-007-3015-1_3. Subcell Biochem. 2012. PMID: 22374088 Free PMC article. Review.
Cited by
- The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion.
Gireud-Goss M, Reyes S, Tewari R, Patrizz A, Howe MD, Kofler J, Waxham MN, McCullough LD, Bean AJ. Gireud-Goss M, et al. Mol Cell Neurosci. 2020 Oct;108:103542. doi: 10.1016/j.mcn.2020.103542. Epub 2020 Aug 22. Mol Cell Neurosci. 2020. PMID: 32841720 Free PMC article. - Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III.
Richter CM, West M, Odorizzi G. Richter CM, et al. J Cell Sci. 2013 Apr 15;126(Pt 8):1881-90. doi: 10.1242/jcs.122499. Epub 2013 Feb 26. J Cell Sci. 2013. PMID: 23444383 Free PMC article. - Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression.
Wang S, Sun J, Dastgheyb RM, Li Z. Wang S, et al. Front Immunol. 2022 Nov 2;13:1045624. doi: 10.3389/fimmu.2022.1045624. eCollection 2022. Front Immunol. 2022. PMID: 36405712 Free PMC article. Review. - The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation.
Schuh AL, Hanna M, Quinney K, Wang L, Sarkeshik A, Yates JR 3rd, Audhya A. Schuh AL, et al. Biochem J. 2015 Mar 15;466(3):625-37. doi: 10.1042/BJ20141202. Biochem J. 2015. PMID: 25588614 Free PMC article. - The Nitrosopumilus maritimus CdvB, but not FtsZ, assembles into polymers.
Ng KH, Srinivas V, Srinivasan R, Balasubramanian M. Ng KH, et al. Archaea. 2013;2013:104147. doi: 10.1155/2013/104147. Epub 2013 Jun 2. Archaea. 2013. PMID: 23818813 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases