Cholesterol, lipid rafts, and disease - PubMed (original) (raw)

Review

Cholesterol, lipid rafts, and disease

Kai Simons et al. J Clin Invest. 2002 Sep.

No abstract available

PubMed Disclaimer

Figures

Figure 1

Figure 1

Mechanisms of raft clustering. (a) Rafts (red) are small at the plasma membrane, containing only a subset of proteins. (b) Raft size is increased by clustering, leading to a new mixture of molecules. This clustering can be triggered (1) at the extracellular side by ligands, antibodies, or lectins, (2) within the membrane by oligomerization, or (3) by cytosolic agents (cytoskeletal elements, adapters, scaffolds). Raft clustering occurs at the plasma membrane as well as intracellularly, e.g., in endosomal lumen. Ligand binding or oligomerization can alter the partitioning of proteins in and out of rafts. Increased raft affinity of a given protein and its activation within rafts (e.g., phosphorylation by Src-family kinases [yellow]) can initiate a cascade of events, leading to further increase of raft size by clustering.

Similar articles

Cited by

References

    1. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000;1:31–39. - PubMed
    1. London E, Brown DA. Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts) Biochim Biophys Acta. 2000; 1508:182–195. - PubMed
    1. Brown DA, London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol. 1998;14:111–136. - PubMed
    1. Jeong J, McMahon AP. Cholesterol modification of Hedgehog family proteins. J Clin Invest. 2002;110:591–596. doi:10.1172/JCI200216506. - PMC - PubMed
    1. Harder T, et al. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol. 1998;141:929–942. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources