Beyond the role of glutamate as a neurotransmitter - PubMed (original) (raw)
Review
doi: 10.1038/nrn916.
Affiliations
- PMID: 12209123
- DOI: 10.1038/nrn916
Review
Beyond the role of glutamate as a neurotransmitter
Maiken Nedergaard et al. Nat Rev Neurosci. 2002 Sep.
Abstract
Glutamate is the principal excitatory neurotransmitter of the central nervous system, but many studies have expanded its functional repertoire by showing that glutamate receptors are present in a variety of non-excitable cells. How does glutamate receptor activation modulate their activity? Do non-excitable cells release glutamate, and, if so, how? These questions remain enigmatic. Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes.
Similar articles
- NMDA Receptors in glia.
Verkhratsky A, Kirchhoff F. Verkhratsky A, et al. Neuroscientist. 2007 Feb;13(1):28-37. doi: 10.1177/1073858406294270. Neuroscientist. 2007. PMID: 17229973 Review. - Novel aspects of glutamatergic signalling in the neuroendocrine system.
Hrabovszky E, Liposits Z. Hrabovszky E, et al. J Neuroendocrinol. 2008 Jun;20(6):743-51. doi: 10.1111/j.1365-2826.2008.01719.x. J Neuroendocrinol. 2008. PMID: 18601697 Review. - The role of glutamate in central nervous system health and disease--a review.
Platt SR. Platt SR. Vet J. 2007 Mar;173(2):278-86. doi: 10.1016/j.tvjl.2005.11.007. Epub 2005 Dec 22. Vet J. 2007. PMID: 16376594 Review. - Cultures of rat astrocytes challenged with a steady supply of glutamate: new model to study flux distribution in the glutamate-glutamine cycle.
Fonseca LL, Monteiro MA, Alves PM, Carrondo MJ, Santos H. Fonseca LL, et al. Glia. 2005 Sep;51(4):286-96. doi: 10.1002/glia.20209. Glia. 2005. PMID: 15834952 - Synaptic modulation by astrocytes via Ca2+-dependent glutamate release.
Santello M, Volterra A. Santello M, et al. Neuroscience. 2009 Jan 12;158(1):253-9. doi: 10.1016/j.neuroscience.2008.03.039. Epub 2008 Mar 22. Neuroscience. 2009. PMID: 18455880 Review.
Cited by
- Disrupted glutamate homeostasis as a target for glioma therapy.
Biegański M, Szeliga M. Biegański M, et al. Pharmacol Rep. 2024 Sep 11. doi: 10.1007/s43440-024-00644-y. Online ahead of print. Pharmacol Rep. 2024. PMID: 39259492 Review. - Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture.
Minamihata T, Takano-Kawabe K, Moriyama M. Minamihata T, et al. Neurol Int. 2024 Jul 4;16(4):709-730. doi: 10.3390/neurolint16040054. Neurol Int. 2024. PMID: 39051215 Free PMC article. - Photorefraction Simulates Well the Plasticity of Neural Synaptic Connections.
Bile A, Tari H, Pepino R, Nabizada A, Fazio E. Bile A, et al. Biomimetics (Basel). 2024 Apr 13;9(4):231. doi: 10.3390/biomimetics9040231. Biomimetics (Basel). 2024. PMID: 38667243 Free PMC article. - Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation.
Teng L, Qin Q, Zhou Z, Zhou F, Cao C, Yang J, Ding J. Teng L, et al. Sci Rep. 2023 Nov 4;13(1):19069. doi: 10.1038/s41598-023-46477-2. Sci Rep. 2023. PMID: 37925518 Free PMC article. - An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection.
Choi HK, Choi JH, Yoon J. Choi HK, et al. Biosensors (Basel). 2023 Sep 19;13(9):892. doi: 10.3390/bios13090892. Biosensors (Basel). 2023. PMID: 37754127 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources