The interplay of dendritic cell subsets in systemic lupus erythematosus - PubMed (original) (raw)

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The interplay of dendritic cell subsets in systemic lupus erythematosus

A Karolina Palucka et al. Immunol Cell Biol. 2002 Oct.

Abstract

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

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