Autorhythmometry in manic-depressives - PubMed (original) (raw)
Case Reports
. 1975 Oct-Dec;2(4):325-35.
- PMID: 1222678
Case Reports
Autorhythmometry in manic-depressives
M Atkinson et al. Chronobiologia. 1975 Oct-Dec.
Abstract
Three manic-depressives were studied longitudinally. Several times a day, the patients measured and recorded their mood, vigor, oral temperature, finger counting, blood pressure, pulse rate, and urine volume. Then the acrophases of their circadian rhythms were computed by a least-squares fit. These patients displayed rhythm phases that were grossly abnormal. Systematic acrophase changes over time supported the hypothesis that manic-depressives have circadian rhythms that free-run faster than one cycle per 24 hrs. Lithium appeared to slow these rhythms and help the environmental synchronizer force physiological functions to coordinate better with the usual 24-h environmental cycles.
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