Invited review: Active fluid clearance from the distal air spaces of the lung - PubMed (original) (raw)
Review
Invited review: Active fluid clearance from the distal air spaces of the lung
Michael A Matthay et al. J Appl Physiol (1985). 2002 Oct.
Free article
Abstract
Active ion transport drives iso-osmolar alveolar fluid clearance, a hypothesis originally suggested by in vivo studies in sheep 20 yr ago. Over the last two decades, remarkable progress has been made in establishing a critical role for active sodium transport as a primary mechanism that drives fluid clearance from the distal air spaces of the lung. The rate of fluid transport can be increased in most species, including the human lung, by cAMP stimulation. Catecholamine-independent mechanisms, including hormones, growth factors, and cytokines, can also upregulate epithelial fluid clearance in the lung. The new insights into the role of the distal lung epithelium in actively regulating lung fluid balance has important implications for the resolution of clinical pulmonary edema.
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