Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study - PubMed (original) (raw)

. 2002 Oct 1;95(7):1421-33.

doi: 10.1002/cncr.10866.

Affiliations

• PMID: 12237910
• DOI: 10.1002/cncr.10866

Free article

Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study

Erik J M Konings et al. Cancer. 2002.

Free article

Abstract

Background: Several studies have reported inverse associations between folate intake and colorectal carcinoma risk. Few were prospective studies and none evaluated the association between the intake of individual folate vitamers and colorectal carcinoma risk.

Methods: The aim of the current study was to investigate the relationship between dietary folate intake and the risk of colorectal carcinoma in a large prospective cohort study in The Netherlands comprising 120,852 men and women aged 55-69 years. After 7.3 years of follow-up, 760 colon and 411 rectal carcinoma cases were available for analysis. Data processing and analysis used the case-cohort approach. A new Dutch database was used to estimate intakes of total and individual folate vitamers.

Results: Analyses adjusted for age, energy intake, family history of colorectal carcinoma, alcohol, vitamin C, iron, and dietary fiber intake yielded an inverse association between colon carcinoma risk and total dietary folate intake (rate ratio [RR]highest vs. lowest quintile, men: 0.73; 95% confidence interval [CI], 0.46-1.17, P trend = 0.03; women: 0.68; 95% CI, 0.39-1.20, P trend = 0.18). An inverse association between rectal carcinoma and total dietary folate intake was found only among men (RR highest vs. lowest quintile, men: 0.66; 95% CI, 0.35-1.21, P trend = 0.03). Analyses showed no clear difference in colorectal carcinoma risk associated with intake of different folate vitamers.

Conclusions: Dietary folate intake was related inversely to colon and male rectal carcinoma risk.

Copyright 2002 American Cancer Society.DOI 10.1002/cncr.10866

PubMed Disclaimer

Similar articles

• Dietary folate and folate vitamers and the risk of pancreatic cancer in the Netherlands cohort study.
  Keszei AP, Verhage BA, Heinen MM, Goldbohm RA, van den Brandt PA. Keszei AP, et al. Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1785-91. doi: 10.1158/1055-9965.EPI-08-1220. Cancer Epidemiol Biomarkers Prev. 2009. PMID: 19505911
• A prospective study of dietary folate intake and risk of colorectal cancer: modification by caffeine intake and cigarette smoking.
  Larsson SC, Giovannucci E, Wolk A. Larsson SC, et al. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):740-3. doi: 10.1158/1055-9965.EPI-04-0581. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15767361
• Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies.
  Kampman E, Giovannucci E, van 't Veer P, Rimm E, Stampfer MJ, Colditz GA, Kok FJ, Willett WC. Kampman E, et al. Am J Epidemiol. 1994 Jan 1;139(1):16-29. doi: 10.1093/oxfordjournals.aje.a116931. Am J Epidemiol. 1994. PMID: 8296771 Review.
• Soy consumption and colorectal cancer.
  Spector D, Anthony M, Alexander D, Arab L. Spector D, et al. Nutr Cancer. 2003;47(1):1-12. doi: 10.1207/s15327914nc4701_1. Nutr Cancer. 2003. PMID: 14769532 Review.

Cited by

• A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation.
  Bruce WR, Cirocco M, Giacca A, Kim YI, Marcon N, Minkin S. Bruce WR, et al. Br J Cancer. 2005 Sep 19;93(6):639-46. doi: 10.1038/sj.bjc.6602770. Br J Cancer. 2005. PMID: 16136044 Free PMC article. Clinical Trial.
• Low folate levels may protect against colorectal cancer.
  Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A, Palmqvist R. Van Guelpen B, et al. Gut. 2006 Oct;55(10):1461-6. doi: 10.1136/gut.2005.085480. Epub 2006 Apr 25. Gut. 2006. PMID: 16638790 Free PMC article.
• Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).
  Williams EA, Welfare M, Spiers A, Hill MH, Bal W, Gibney ER, Duckworth Y, Powers HJ, Mathers JC. Williams EA, et al. Eur J Nutr. 2013 Oct;52(7):1801-10. doi: 10.1007/s00394-012-0483-5. Epub 2012 Dec 28. Eur J Nutr. 2013. PMID: 23271614
• Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
  Murtaugh MA, Curtin K, Sweeney C, Wolff RK, Holubkov R, Caan BJ, Slattery ML. Murtaugh MA, et al. Cancer Causes Control. 2007 Mar;18(2):153-63. doi: 10.1007/s10552-006-0099-2. Epub 2007 Jan 23. Cancer Causes Control. 2007. PMID: 17245555 Free PMC article.
• Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States.
  Gibson TM, Weinstein SJ, Pfeiffer RM, Hollenbeck AR, Subar AF, Schatzkin A, Mayne ST, Stolzenberg-Solomon R. Gibson TM, et al. Am J Clin Nutr. 2011 Oct;94(4):1053-62. doi: 10.3945/ajcn.110.002659. Epub 2011 Aug 3. Am J Clin Nutr. 2011. PMID: 21813806 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Medical

  • MedlinePlus Health Information