Cholecystokinin: a putative satiety signal - PubMed (original) (raw)
- PMID: 1226392
Cholecystokinin: a putative satiety signal
G P Smith et al. Pharmacol Biochem Behav. 1975.
Abstract
The intestinal hormone cholecystokinin (CCK) elicits satiety in rats and inhibits food intake in rhesus monkeys. This behavioral effect is specifically related to the C-terminal octapeptide structure of CCK and is a new biological effect of the hormone. Endogenous CCK released by food entering the duodenum may inhibit feeding and elicit satiety under physiological conditions, but no experimental evidence is availabe on this point. Until such evidence becomes available, we believe that CCK should be considered a putative satiety signal. The satiety effect of CCK suggests a therapeutic role of CCK for human hyperphagia and obesity. An interesting therapeutic alternative to administration of exogenous CCK is the release of endogenous CCK by nutrients such as amino acids. These nutrients can be ingested as preloads which are calorically trivial, but which release significant amounts of CCK. Such preloads inhibit food intake in rhesus monkeys. Their efficacy in man has not been determined.
Similar articles
- Cholecystokinin and satiety in rats and rhesus monkeys.
Gibbs J, Smith GP. Gibbs J, et al. Am J Clin Nutr. 1977 May;30(5):758-61. doi: 10.1093/ajcn/30.5.758. Am J Clin Nutr. 1977. PMID: 404865 - Dose-response effects of PEGylated cholecystokinin on the behavioral satiety sequence.
Verbaeys I, León-Tamariz F, De Buyser K, Buyse J, Decuypere E, Pottel H, Cokelaere M. Verbaeys I, et al. Physiol Behav. 2009 Aug 4;98(1-2):198-204. doi: 10.1016/j.physbeh.2009.05.010. Epub 2009 May 22. Physiol Behav. 2009. PMID: 19465039 - Central nervous system cholecystokinin and the control of feeding behavior in sheep.
Della-Fera MA, Baile CA. Della-Fera MA, et al. Prog Clin Biol Res. 1985;192:115-22. Prog Clin Biol Res. 1985. PMID: 3001747 - Role of cholecystokinin in the control of food intake.
Peikin SR. Peikin SR. Gastroenterol Clin North Am. 1989 Dec;18(4):757-75. Gastroenterol Clin North Am. 1989. PMID: 2693351 Review. - The satiety effect of cholecystokinin. Recent progress and current problems.
Smith GP, Gibbs J. Smith GP, et al. Ann N Y Acad Sci. 1985;448:417-23. doi: 10.1111/j.1749-6632.1985.tb29936.x. Ann N Y Acad Sci. 1985. PMID: 3896096 Review.
Cited by
- Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors.
Li AJ, Wang Q, Dinh TT, Simasko SM, Ritter S. Li AJ, et al. Am J Physiol Regul Integr Comp Physiol. 2016 Apr 15;310(8):R724-32. doi: 10.1152/ajpregu.00387.2015. Epub 2016 Jan 20. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26791830 Free PMC article. - The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. de Lecea L, et al. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7. doi: 10.1073/pnas.95.1.322. Proc Natl Acad Sci U S A. 1998. PMID: 9419374 Free PMC article. - Activity in nodose ganglia neurons after treatment with CP 55,940 and cholecystokinin.
Johnston JR, Freeman KG, Edwards GL. Johnston JR, et al. Physiol Rep. 2018 Dec;6(23):e13927. doi: 10.14814/phy2.13927. Physiol Rep. 2018. PMID: 30512249 Free PMC article. - TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1.
Shah BP, Liu P, Yu T, Hansen DR, Gilbertson TA. Shah BP, et al. Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C210-9. doi: 10.1152/ajpcell.00209.2011. Epub 2011 Oct 12. Am J Physiol Cell Physiol. 2012. PMID: 21998136 Free PMC article. - Deletion of GPR40 fatty acid receptor gene in mice blocks mercaptoacetate-induced feeding.
Li AJ, Wiater MF, Wang Q, Wank S, Ritter S. Li AJ, et al. Am J Physiol Regul Integr Comp Physiol. 2016 May 15;310(10):R968-74. doi: 10.1152/ajpregu.00548.2015. Epub 2016 Mar 16. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26984894 Free PMC article.