Integrins: bidirectional, allosteric signaling machines - PubMed (original) (raw)

Review

. 2002 Sep 20;110(6):673-87.

doi: 10.1016/s0092-8674(02)00971-6.

Affiliations

• PMID: 12297042
• DOI: 10.1016/s0092-8674(02)00971-6

Free article

Review

Integrins: bidirectional, allosteric signaling machines

Richard O Hynes. Cell. 2002.

Free article

Abstract

In their roles as major adhesion receptors, integrins signal across the plasma membrane in both directions. Recent structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways. Long-range conformational changes couple these functions via allosteric equilibria.

PubMed Disclaimer

Similar articles

• Cell adhesion in vascular biology. New insights into integrin-ligand interaction.
  Loftus JC, Liddington RC. Loftus JC, et al. J Clin Invest. 1997 May 15;99(10):2302-6. doi: 10.1172/JCI119408. J Clin Invest. 1997. PMID: 9153268 Free PMC article. Review. No abstract available.
• The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion.
  Springer TA, Wang JH. Springer TA, et al. Adv Protein Chem. 2004;68:29-63. doi: 10.1016/S0065-3233(04)68002-8. Adv Protein Chem. 2004. PMID: 15500858 Review.
• Structures of integrin domains and concerted conformational changes in the bidirectional signaling mechanism of alphaIIbbeta3.
  Calvete JJ. Calvete JJ. Exp Biol Med (Maywood). 2004 Sep;229(8):732-44. doi: 10.1177/153537020422900805. Exp Biol Med (Maywood). 2004. PMID: 15337827 Review.
• Integrin-linked kinase: integrin's mysterious partner.
  Grashoff C, Thievessen I, Lorenz K, Ussar S, Fässler R. Grashoff C, et al. Curr Opin Cell Biol. 2004 Oct;16(5):565-71. doi: 10.1016/j.ceb.2004.07.004. Curr Opin Cell Biol. 2004. PMID: 15363808 Review.
• Integrin structure, allostery, and bidirectional signaling.
  Arnaout MA, Mahalingam B, Xiong JP. Arnaout MA, et al. Annu Rev Cell Dev Biol. 2005;21:381-410. doi: 10.1146/annurev.cellbio.21.090704.151217. Annu Rev Cell Dev Biol. 2005. PMID: 16212500 Review.

Cited by

• FNDC1 is a myokine that promotes myogenesis and muscle regeneration.
  Zhang RX, Zhai YY, Ding RR, Huang JH, Shi XC, Liu H, Liu XP, Zhang JF, Lu JF, Zhang Z, Leng XK, Li F, Xiao JY, Xia B, Wu JW. Zhang RX, et al. EMBO J. 2024 Nov 20. doi: 10.1038/s44318-024-00285-0. Online ahead of print. EMBO J. 2024. PMID: 39567831
• Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.
  Wang C, Chen Y, Zhao J, Feng X, Ma R, Wang H, Xue L, Tian J, Yang L, Gu Y, Zhang J. Wang C, et al. Front Vet Sci. 2024 Oct 30;11:1435128. doi: 10.3389/fvets.2024.1435128. eCollection 2024. Front Vet Sci. 2024. PMID: 39545257 Free PMC article.
• YIGSR, A Laminin-Derived Peptide, Dictates a Concentration-Dependent Impact on Macrophage Phenotype Response.
  Jha A, Moore E. Jha A, et al. Cell Mol Bioeng. 2024 Jul 26;17(5):423-440. doi: 10.1007/s12195-024-00810-5. eCollection 2024 Oct. Cell Mol Bioeng. 2024. PMID: 39513005
• Mechanosensory entities and functionality of endothelial cells.
  Mierke CT. Mierke CT. Front Cell Dev Biol. 2024 Oct 23;12:1446452. doi: 10.3389/fcell.2024.1446452. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39507419 Free PMC article. Review.
• The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation.
  Yu K, Wang GM, Guo SS, Bassermann F, Fässler R. Yu K, et al. EMBO Rep. 2024 Dec;25(12):5687-5718. doi: 10.1038/s44319-024-00300-9. Epub 2024 Nov 6. EMBO Rep. 2024. PMID: 39506038 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource
  • Guide to Pharmacology